Protein Info for MIT1002_03553 in Alteromonas macleodii MIT1002

Annotation: Na(+)/H(+) antiporter regulatory protein

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 296 PF00126: HTH_1" amino acids 7 to 64 (58 residues), 57.8 bits, see alignment E=8.5e-20 PF03466: LysR_substrate" amino acids 93 to 257 (165 residues), 35.6 bits, see alignment E=6.6e-13

Best Hits

KEGG orthology group: K03717, LysR family transcriptional regulator, transcriptional activator of nhaA (inferred from 95% identity to amc:MADE_00631)

Predicted SEED Role

"regulatory protein, LysR"

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Search structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

Find the best match in UniProt

Protein Sequence (296 amino acids)

>MIT1002_03553 Na(+)/H(+) antiporter regulatory protein (Alteromonas macleodii MIT1002)
MHHLNYHHLYYFYLVAREGSIAKAAKLLHVTPQTVSGQLSTFENQLGYSLFDRINKRLYL
NARGKVSYQYASEIFHKGNQLAEILNNSDEVNTKEFVIGITNGIPKVLFYDFVHATMRRF
SQVKYVIKEDSFDGLLKELAINAIDFILADRGIAPGTQISANSFFLGESSLSFFARAPLT
EEQTFPECLNQMPLLIQGNTSGIRQALTSWLETEQLYPKVVAEFDDTALLKLFGSEDFGV
FCAPSAISKHVEEQYGVHCIGNASTLNERYYAINGKSRADYTISEAIVEAARGILA