Protein Info for MIT1002_03473 in Alteromonas macleodii MIT1002

Annotation: 5-keto-D-gluconate transporter

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 300 350 400 446 transmembrane" amino acids 7 to 23 (17 residues), see Phobius details amino acids 29 to 50 (22 residues), see Phobius details amino acids 61 to 80 (20 residues), see Phobius details amino acids 104 to 130 (27 residues), see Phobius details amino acids 141 to 159 (19 residues), see Phobius details amino acids 172 to 199 (28 residues), see Phobius details amino acids 228 to 248 (21 residues), see Phobius details amino acids 260 to 282 (23 residues), see Phobius details amino acids 303 to 322 (20 residues), see Phobius details amino acids 342 to 369 (28 residues), see Phobius details amino acids 378 to 401 (24 residues), see Phobius details amino acids 421 to 445 (25 residues), see Phobius details TIGR00791: transporter, gluconate:H+ symporter (GntP) family" amino acids 7 to 445 (439 residues), 430.8 bits, see alignment E=3.3e-133 PF02447: GntP_permease" amino acids 7 to 443 (437 residues), 461.9 bits, see alignment E=1e-142

Best Hits

Swiss-Prot: 39% identical to GNTU_ECO57: Low-affinity gluconate transporter (gntU) from Escherichia coli O157:H7

KEGG orthology group: None (inferred from 80% identity to alt:ambt_09185)

MetaCyc: 39% identical to low-affinity gluconate transporter (Escherichia coli K-12 substr. MG1655)
TRANS-RXN0-209

Predicted SEED Role

"Low-affinity gluconate/H+ symporter GntU" in subsystem D-gluconate and ketogluconates metabolism

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Search structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

Find the best match in UniProt

Protein Sequence (446 amino acids)

>MIT1002_03473 5-keto-D-gluconate transporter (Alteromonas macleodii MIT1002)
MTDTFSLLFVAICSIVLLTYLVVVRKVHAFIAILVAAAFVGLGTGMQAADVLASMQSGMG
NTLGFVATIVGLGAMFGQFLEESGGIDRLSQTINNKFGDKNSQWAVVLTGFLVAIPVFFE
VGLIILMPLIYSLAKKSGKSLIYYGIPLTAGLAVTHAFIPPTPGPVAVASILGADIGLVI
LFGFIVGIPCACLAGPIYATFLAKRLHVPVPNHIIEASHKKPMELPSFGSVAALLTFPLV
AILVGTLAKFTLSEGVLKEALLFIGHPFIALTIATIACFKVLGKKQGLSSEQIRNIASRG
LEPVALVILVTGAGGMFKQVLIDSGAGQAFADVVALSPLPPLAAGFLIAISVRIIQGSAT
VAMLTAAGLMGPVVQELAFSPSVLALMTIAIAAGATAMSHVNDTGFWIVNRYFDISVKDT
FVSWTCMATLIGFIGLFLVLMLGLFV