Protein Info for MIT1002_03469 in Alteromonas macleodii MIT1002

Annotation: Rut operon repressor

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 224 PF00440: TetR_N" amino acids 35 to 80 (46 residues), 48.4 bits, see alignment 6.6e-17 PF08362: TetR_C_3" amino acids 83 to 223 (141 residues), 183.1 bits, see alignment E=2.8e-58

Best Hits

Swiss-Prot: 53% identical to RUTR_ECO57: HTH-type transcriptional regulator RutR (rutR) from Escherichia coli O157:H7

KEGG orthology group: K09017, TetR/AcrR family transcriptional regulator (inferred from 87% identity to amc:MADE_00759)

Predicted SEED Role

"Transcriptional regulator RutR of pyrimidine catabolism (TetR family)" in subsystem Pyrimidine utilization

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Search structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

Find the best match in UniProt

Protein Sequence (224 amino acids)

>MIT1002_03469 Rut operon repressor (Alteromonas macleodii MIT1002)
MSKSEGQTITKSARAFSPTTQKRREKALLEKRTRIMDAALSLFSKNGVSGTTIEQVSELA
NVSKSNLLYYFKSKEGLYLSVITHLLDVWLTPLQSFSAEQDPIETLSDYIKVKLEMSRDN
PAESKLFCMEVVQGAPLLIKELETPLKTLLDAKSAVIIEWIEAGKLKPVDPIHLIFSIWA
ITQHYADFSVQIKAVTGKDLSDPAFFESTLSNIQHIILGGLKPA