Protein Info for MIT1002_03093 in Alteromonas macleodii MIT1002

Annotation: FMN-dependent NADPH-azoreductase

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 255 TIGR02690: arsenical resistance protein ArsH" amino acids 40 to 241 (202 residues), 389 bits, see alignment E=2.1e-121 PF03358: FMN_red" amino acids 49 to 192 (144 residues), 117.8 bits, see alignment E=1.6e-38

Best Hits

Swiss-Prot: 71% identical to ARREH_RHIME: NADPH-dependent FMN reductase ArsH (arsH) from Rhizobium meliloti (strain 1021)

KEGG orthology group: K11811, arsenical resistance protein ArsH (inferred from 96% identity to amc:MADE_03335)

MetaCyc: 75% identical to ArsH (Pseudomonas putida KT2440)

Predicted SEED Role

"Arsenic resistance protein ArsH" in subsystem Arsenic resistance

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Compare to protein structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

Find the best match in UniProt

Protein Sequence (255 amino acids)

>MIT1002_03093 FMN-dependent NADPH-azoreductase (Alteromonas macleodii MIT1002)
MGNSKSMSQDISSNQESSTAQSPSDNAVMAQMHKPIMANFASGFSDHKPRILLLYGSLRE
RSYSRLVIEESARLLEYFGAEAKIFDPRGLPQPDTEDDSHPKVKELRELMMWSEGQIWCS
PERHGSMTGIMKSMIDWVPLSLGGVRPTQGKTLAIMQVSGGSQSFNAVNQMRILGRWMRM
LTIPNQSSVAKAFLEFEDDGRMKPSPYYNRIVDVVEELVKFTLLTRDNKDFLVDRYSERV
ESAEEVSKRVNQKSL