Protein Info for MIT1002_02971 in Alteromonas macleodii MIT1002

Annotation: Glycine dehydrogenase [decarboxylating]

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

• PF02347: GDC-P
  • amino acids 19 to 442 (424 residues), 614.5 bits, E=1.6e-188
  • amino acids 465 to 740 (276 residues), 28.8 bits, E=9.3e-11
• TIGR00461: glycine dehydrogenase
  • amino acids 20 to 956 (937 residues), 1590.7 bits, E=0
• PF21478: GcvP2_C
  • amino acids 784 to 905 (122 residues), 201.8 bits, E=3.9e-64

Best Hits

Swiss-Prot: 71% identical to GCSP1_COLP3: Glycine dehydrogenase (decarboxylating) 1 (gcvP1) from Colwellia psychrerythraea (strain 34H / ATCC BAA-681)

KEGG orthology group: K00281, glycine dehydrogenase [EC: 1.4.4.2] (inferred from 98% identity to amc:MADE_00863)

MetaCyc: 68% identical to glycine decarboxylase (Escherichia coli K-12 substr. MG1655)
Glycine dehydrogenase (decarboxylating). [EC: 1.4.1.27, 1.4.4.2]

Predicted SEED Role

"Glycine dehydrogenase [decarboxylating] (glycine cleavage system P protein) (EC 1.4.4.2)" in subsystem Glycine and Serine Utilization or Glycine cleavage system or Photorespiration (oxidative C2 cycle) (EC 1.4.4.2)

MetaCyc Pathways

• folate transformations III (E. coli) (9/9 steps found)
• folate transformations II (plants) (10/11 steps found)
• glycine biosynthesis II (3/3 steps found)
• glycine cleavage (3/3 steps found)
• glycine degradation (3/3 steps found)
• photorespiration I (7/9 steps found)
• folate transformations I (9/13 steps found)
• photorespiration III (6/9 steps found)
• photorespiration II (6/10 steps found)
• reductive glycine pathway of autotrophic CO₂ fixation (5/9 steps found)

KEGG Metabolic Maps

• Glycine, serine and threonine metabolism

Isozymes

No predicted isozymes

Use Curated BLAST to search for 1.4.1.27 or 1.4.4.2

Protein Sequence (965 amino acids)

>MIT1002_02971 Glycine dehydrogenase [decarboxylating] (Alteromonas macleodii MIT1002)
MSNTSPTLAQLEQKDTFIRRHIGPGKGEIEEMLSAIGASSLDDLIEQTVPAGIALPEPLK
CGEGATEVEALSELKAVAQKNKINRSFIGMGYYDTHVPNVILRNVLENPGWYTAYTPYQP
EIAQGRLEAILNFQQVTIDLTGLELASASLLDEGTAAAEAMGLAKRVSKNKKANAFFIAN
DVHPQTVDVVETRAEMFGFEIIKGAAEEAAEHDVFGALLQYPTSTGEVKDISDIIAAVQE
KKGIVAVAADLMSLVMLKSPGELGADVALGSAQRFGVPMGYGGPHAAFFATRDSYKRSLP
GRIIGVSKDTRGRPALRMALQTREQHIRREKANSNICTAQVLLANMASFYAVYHGPQGLK
TIAERIHRFADILATGLNQKGVALKHSTYFDTLTVMVDNKEDVLAKAYAKGMNLRADLEG
AVGVSLDETTTREDIVALFDVLLGEEHGLTVEGLDAEVTTQDVKSIPEGLVRTSDFLTHE
VFNKYHSETEMLRYIKSLENKDLALNHSMISLGSCTMKLNATAEMIPVTWAEFGQLHPFA
PLDQAAGYQEMIAELSEWLINVTGYDALSMQPNSGAQGEYAGLLAIQRYHESRGEGHRNV
CLIPSSAHGTNPASAQMVSLKVVVVACDSKGNVDLNDLRKKAEEVGDNLSCAMITYPSTH
GVYEETVREICDIVHQYGGQVYMDGANMNAQVGITSPGFIGSDVSHLNLHKTFCIPHGGG
GPGMGPIGVKSHLAPFLPNHTVVNVETAGKDCGAVSAAPWGSASILPISYMYIKMMGSDG
LRRATEVAILNANYVAKKLEGHFPVLYKGNNGRVAHECIIDLRPLKEASGVTELDIAKRL
NDYGFHAPTMSFPVAGTLMIEPTESEAKYELDRFINAMVSIRQEIAKVESGEWDATDNPL
HNAPHTLADICDSDWNRSYDRMLAAYPAPEVHRNKFWPTVNRIDDVYGDRNLICSCPSIE
SYVEE