Protein Info for MIT1002_02719 in Alteromonas macleodii MIT1002

Annotation: Sigma-24

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 192 TIGR02939: RNA polymerase sigma factor RpoE" amino acids 1 to 190 (190 residues), 325.3 bits, see alignment E=1.4e-101 PF07638: Sigma70_ECF" amino acids 9 to 182 (174 residues), 36.4 bits, see alignment E=1e-12 TIGR02937: RNA polymerase sigma factor, sigma-70 family" amino acids 21 to 184 (164 residues), 113 bits, see alignment E=1.1e-36 PF04542: Sigma70_r2" amino acids 25 to 92 (68 residues), 69.7 bits, see alignment E=2.9e-23 PF08281: Sigma70_r4_2" amino acids 134 to 181 (48 residues), 61.5 bits, see alignment E=9.5e-21 PF04545: Sigma70_r4" amino acids 137 to 181 (45 residues), 38.1 bits, see alignment 1.8e-13

Best Hits

Swiss-Prot: 73% identical to RPOE_ECOLI: ECF RNA polymerase sigma-E factor (rpoE) from Escherichia coli (strain K12)

KEGG orthology group: K03088, RNA polymerase sigma-70 factor, ECF subfamily (inferred from 97% identity to alt:ambt_04255)

MetaCyc: 73% identical to RNA polymerase sigma factor RpoE (Escherichia coli K-12 substr. MG1655)

Predicted SEED Role

"RNA polymerase sigma factor RpoE" in subsystem Transcription initiation, bacterial sigma factors

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Search structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

Find the best match in UniProt

Protein Sequence (192 amino acids)

>MIT1002_02719 Sigma-24 (Alteromonas macleodii MIT1002)
MSEQITDQQLVEKVQRGDKNAFNLLVTRYQHKVMHLVSRYVKNTGDVADVTQEAFIKAYR
ALPNFRGDSAFYTWLYRIAVNSAKNYLVSQGRKPPASDVDADEADFYEGSDALKEQSTPE
RSLLSEEIEETLFKVVEKLPDDLRMAITLREIEGLSYEEIANVMSCPVGTVRSRIFRARE
AIDKVIQPLLEN