Protein Info for MIT1002_02706 in Alteromonas macleodii MIT1002

Annotation: Lon protease 2

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 300 350 400 455 TIGR00416: DNA repair protein RadA" amino acids 1 to 451 (451 residues), 725.9 bits, see alignment E=8.7e-223 PF18073: Zn_ribbon_LapB" amino acids 8 to 35 (28 residues), 41 bits, see alignment (E = 3.7e-14) PF13481: AAA_25" amino acids 75 to 222 (148 residues), 41.5 bits, see alignment E=3.7e-14 PF06745: ATPase" amino acids 78 to 142 (65 residues), 36.4 bits, see alignment E=1.2e-12 PF13541: ChlI" amino acids 346 to 430 (85 residues), 38.9 bits, see alignment E=2.2e-13 PF05362: Lon_C" amino acids 351 to 452 (102 residues), 33.9 bits, see alignment E=7.5e-12

Best Hits

Swiss-Prot: 74% identical to RADA_HAEIN: DNA repair protein RadA (radA) from Haemophilus influenzae (strain ATCC 51907 / DSM 11121 / KW20 / Rd)

KEGG orthology group: K04485, DNA repair protein RadA/Sms (inferred from 98% identity to amc:MADE_02991)

Predicted SEED Role

"DNA repair protein RadA" in subsystem DNA repair, bacterial

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Compare to protein structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

Find the best match in UniProt

Protein Sequence (455 amino acids)

>MIT1002_02706 Lon protease 2 (Alteromonas macleodii MIT1002)
MAKRKTAYVCSDCGAEFPRWQGQCSECKAWNTISEFVVASAKSVARQTTSGYAGQTAAKI
ETLNAIDLESLPRFSSTFKELDRVLGGGIVPGAAMLIGGSPGAGKSTLLLQVMCQMAKSE
TALYVTGEESLQQVAMRAKRLNLPDDKLMMLAETNVETICDLALTKKPKIMVIDSIQVMH
VTDVQSAPGSVSQVRESAAYLTRFAKQNHIAMFIVGHVTKDGNLAGPKVLEHCIDSSMML
EGESDGRYRTLRSHKNRFGAVNELGVFAMTEKGLKEVSNPSAIFLSRGDNETPGSSVMVI
WEGTRPLLVEIQALVDYSQMSNPRRIAVGLDQNRLSMLLAVLHRHGNVQMNDQDVFVNVV
GGVRVSETSADLALLLAMISSFRNRSLPRDLIVFGEVGLAGEIRPVPNGTERIIEAAKHG
FKRAIVPKANAPKQAINGMKVVPVARLSEALDALE