Protein Info for MIT1002_02581 in Alteromonas macleodii MIT1002

Annotation: Disulfide oxidoreductase

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 175 transmembrane" amino acids 17 to 37 (21 residues), see Phobius details amino acids 48 to 66 (19 residues), see Phobius details amino acids 73 to 90 (18 residues), see Phobius details amino acids 149 to 170 (22 residues), see Phobius details PF02600: DsbB" amino acids 15 to 163 (149 residues), 143.5 bits, see alignment E=3.5e-46

Best Hits

Swiss-Prot: 53% identical to DSBB_PSEA6: Disulfide bond formation protein B (dsbB) from Pseudoalteromonas atlantica (strain T6c / ATCC BAA-1087)

KEGG orthology group: K03611, disulfide bond formation protein DsbB (inferred from 96% identity to amc:MADE_01146)

Predicted SEED Role

"Periplasmic thiol:disulfide oxidoreductase DsbB, required for DsbA reoxidation" in subsystem Biogenesis of c-type cytochromes or Periplasmic disulfide interchange

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Compare to protein structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

Find the best match in UniProt

Protein Sequence (175 amino acids)

>MIT1002_02581 Disulfide oxidoreductase (Alteromonas macleodii MIT1002)
MRGIIHSISQWAEHKSSWLVLFATSLALEIAALYFQYGMGLKPCIMCIYQRTAMYGIVLS
ALIVVIKNNGFTRMLGFAGWAVSAGWGVLIAKEHVGILNAANPFFASCEIVPNFPSWLQL
HEWLPAVFAAEGDCLEDSWQFLSMGMAEWMQIIFAAYFAVFAIVFACRLLDKKPF