Protein Info for MIT1002_02580 in Alteromonas macleodii MIT1002

Annotation: Sodium/proton antiporter NhaB

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 300 350 400 450 524 transmembrane" amino acids 20 to 37 (18 residues), see Phobius details amino acids 42 to 62 (21 residues), see Phobius details amino acids 68 to 85 (18 residues), see Phobius details amino acids 93 to 116 (24 residues), see Phobius details amino acids 128 to 165 (38 residues), see Phobius details amino acids 200 to 218 (19 residues), see Phobius details amino acids 238 to 259 (22 residues), see Phobius details amino acids 298 to 330 (33 residues), see Phobius details amino acids 349 to 369 (21 residues), see Phobius details amino acids 389 to 411 (23 residues), see Phobius details amino acids 451 to 470 (20 residues), see Phobius details amino acids 477 to 496 (20 residues), see Phobius details TIGR00774: Na+/H+ antiporter NhaB" amino acids 1 to 510 (510 residues), 833.7 bits, see alignment E=3.7e-255 PF06450: NhaB" amino acids 1 to 510 (510 residues), 864.9 bits, see alignment E=2.4e-264 PF03600: CitMHS" amino acids 72 to 329 (258 residues), 60 bits, see alignment E=2.3e-20

Best Hits

Swiss-Prot: 98% identical to NHAB_ALTMD: Na(+)/H(+) antiporter NhaB (nhaB) from Alteromonas mediterranea (strain DSM 17117 / CIP 110805 / LMG 28347 / Deep ecotype)

KEGG orthology group: K03314, Na+:H+ antiporter, NhaB family (inferred from 98% identity to amc:MADE_01147)

Predicted SEED Role

"Na+/H+ antiporter NhaB" in subsystem ZZ gjo need homes

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Search structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

Find the best match in UniProt

Protein Sequence (524 amino acids)

>MIT1002_02580 Sodium/proton antiporter NhaB (Alteromonas macleodii MIT1002)
MQTSMIAAIYKNFLGHAPDWYKKTIIAFLIVNPFIFMVDPYVAGWTLVIQFIFTLAMALK
CYPLQPGGLLLIEAMFIGMTSPGHMMHEIEVNLEVLLLLVFMVAGIYFMKDLLMYLFTKL
VIKVRNKLILSLSFIFASAFLSAFLDALTVVAVIISVGLGFYSIYHKVASGKEFHSDHDH
TSDDELGSHDLEDFRAFLRNLMMHSAVGTALGGVMTMVGEPQNLIIADKAGWDFVEFFIR
MAPVTIPVFVFGLLTTVILEKTGMFSYGAKLPAAVRQILVDYNDHMDKGRSKRETAKLIV
QALIGVWLIIGLATHMASVGLIGLSVIVLATSMSGVIEEHALGKAFEEALPFTALLCVFF
GVVAVIIDQGLFQPVIHWVLSFEGETQMVMFYLANGVLSMVSDNVFVGSVYITEVTAALQ
AGQITRDQYDMLAVAINTGTNLPSVATPNGQAAFLFLLTSAIAPLLRLSYGRMVMMALPY
TIVLTIVGLLATYIGLADATQVLYDMHLIEHHSAAEAGAQAVGH