Protein Info for MIT1002_02397 in Alteromonas macleodii MIT1002

Annotation: 6-phosphogluconate dehydrogenase, NADP(+)-dependent, decarboxylating

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

• PF03446: NAD_binding_2
  • amino acids 15 to 181 (167 residues), 120.5 bits, E=7.5e-39
• TIGR00873: 6-phosphogluconate dehydrogenase (decarboxylating)
  • amino acids 15 to 507 (493 residues), 603.3 bits, E=1.6e-185
• PF00393: 6PGD
  • amino acids 213 to 505 (293 residues), 433.7 bits, E=3.6e-134

Best Hits

KEGG orthology group: K00033, 6-phosphogluconate dehydrogenase [EC: 1.1.1.44] (inferred from 95% identity to amc:MADE_01255)

Predicted SEED Role

"6-phosphogluconate dehydrogenase, decarboxylating (EC 1.1.1.44)" in subsystem Pentose phosphate pathway (EC 1.1.1.44)

MetaCyc Pathways

• pentose phosphate pathway (8/8 steps found)
• superpathway of glucose and xylose degradation (14/17 steps found)
• pentose phosphate pathway (oxidative branch) I (3/3 steps found)

KEGG Metabolic Maps

• Biosynthesis of alkaloids derived from histidine and purine
• Biosynthesis of plant hormones
• Glutathione metabolism
• Pentose phosphate pathway

Isozymes

No predicted isozymes

Use Curated BLAST to search for 1.1.1.44

Protein Sequence (517 amino acids)

>MIT1002_02397 6-phosphogluconate dehydrogenase, NADP(+)-dependent, decarboxylating (Alteromonas macleodii MIT1002)
MQKKGGNSHEDKSCDIGFIGLGVMGSNLTMNLVDHGYRVACFDLDQNKVESILAKDASER
AENTEPRVEGCSSYTELLSKLKAPHLIIISVPAGDPVDHVCNHLIDAGIHADDIVVDTGN
SLWTDSVAREEQYKGKFIFFSTAVSGGEVGARFGPSLMPSGNPYAWTRIEPVLKAIAAKV
DPETGKPLESHTPGQPVLEGEPCATYIGPVGAGHYVKMVHNGIEYADMQLICETYHVMRQ
ALHMAPAEIAEVFRNWNEGKLNSYLMEISAEVLEQMDPETHQPLVDVILDRAGQKGTGLW
TAVSALQVGSPAQTITSAVFARSISSLKDERVAASKVLTGPAAPTFSDDEKMSIINKLEQ
ALYCSKICAYAQGFQLMAMAGKEHGWTLEFGEIAKIWRAGCIIRAVFLQSISKAYENNED
LANLLMDPFFSEQITQYQADWRESIAQATLAGVPCPAMMSALSYYDSYRTAVLPANLLQG
QRDYFGAHTYQRVDKPAGKKYHIEWSDPARPQTAIKK