Protein Info for MIT1002_02359 in Alteromonas macleodii MIT1002

Annotation: Exodeoxyribonuclease V alpha chain

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 300 350 400 450 500 550 600 650 700 733 TIGR01447: exodeoxyribonuclease V, alpha subunit" amino acids 20 to 716 (697 residues), 405.7 bits, see alignment E=1.8e-125 PF13245: AAA_19" amino acids 200 to 350 (151 residues), 120.6 bits, see alignment E=2.8e-38 PF13604: AAA_30" amino acids 200 to 363 (164 residues), 88.4 bits, see alignment E=2.7e-28 PF13401: AAA_22" amino acids 210 to 334 (125 residues), 28.8 bits, see alignment E=7.1e-10 PF09848: SLFN-g3_helicase" amino acids 211 to 317 (107 residues), 24.7 bits, see alignment E=7e-09 PF05127: NAT10_TcmA_helicase" amino acids 214 to 331 (118 residues), 29.8 bits, see alignment E=2.7e-10 PF01443: Viral_helicase1" amino acids 636 to 694 (59 residues), 26.5 bits, see alignment 2.6e-09 PF13538: UvrD_C_2" amino acids 643 to 694 (52 residues), 49.9 bits, see alignment 1.2e-16

Best Hits

Predicted SEED Role

"Exodeoxyribonuclease V alpha chain (EC 3.1.11.5)" in subsystem DNA-replication (EC 3.1.11.5)

Isozymes

Compare fitness of predicted isozymes for: 3.1.11.5

Use Curated BLAST to search for 3.1.11.5

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Compare to protein structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

Find the best match in UniProt

Protein Sequence (733 amino acids)

>MIT1002_02359 Exodeoxyribonuclease V alpha chain (Alteromonas macleodii MIT1002)
MKSNQHSVPSFFDNLFGIEAIDKFVAKEFGFIDELEQEEQFIWAGILAYLSYMQRNGHSC
IYLKDIAGTTLFKEVVAEQEAALAFETNEHSSNGAAAASLTLVEQTEQEKAPKAGVDVPQ
LTPLLRIVKSALVNEQVAQLFVYSNGKLYSRRYYEFEQEVARNVVKRAALTPLSDEASEK
VKQLWPAIFPTETTDRQDWQQIAVAKSLMQRFCVINGGPGTGKTYTVLRLLLALQACDEN
LKIVLAAPTGKAQQRMTESIMNSIDGLRGKLNDTVLNNVPTDAVTLHRLLGLREHGVSTK
FNQHNQLAADVLIVDEASMVDLALMTRIVRALPDHARLYFIGDADQLPAVELGNVLEQLV
STGPACFDDNANVPNGTNSAHSSLSLNSHDDAFSLGGVPSSMRQHIATLCPHLPLLPVDE
QAKSYVATLQAPQRFKGQVAKVATAIQRGDASGALTAINDQADANDESAGLGSNTASRLQ
SGVHLWPELQVSGRDLQQLAKESFLPIFDAGSAEEALNRLNVVRWLTPVRKGGMGVEGLN
NLVFDAIKHKIRKREGHFYQGQPIMIVKNHHPQRLSNGEVGVIWPDSKGKLYAWFYQDSQ
ASGQNGSSQKASANAGDSADKTLAQKQALRSISLSRVPQFETVYAMTIHKSQGSEFNHVV
LILPKPDSEKAANLFHRGLVYTGLTRAKDGCLIISDNATFTHMVQRVDKRYSGLSEVISL
HLESTSNATPEIE