Protein Info for MIT1002_02302 in Alteromonas macleodii MIT1002

Annotation: Cation efflux system protein CzcA

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 100 200 300 400 500 600 700 800 900 1000 1127 transmembrane" amino acids 12 to 32 (21 residues), see Phobius details amino acids 338 to 357 (20 residues), see Phobius details amino acids 364 to 382 (19 residues), see Phobius details amino acids 389 to 411 (23 residues), see Phobius details amino acids 455 to 474 (20 residues), see Phobius details amino acids 486 to 507 (22 residues), see Phobius details amino acids 547 to 571 (25 residues), see Phobius details amino acids 577 to 597 (21 residues), see Phobius details amino acids 609 to 628 (20 residues), see Phobius details amino acids 940 to 957 (18 residues), see Phobius details amino acids 968 to 986 (19 residues), see Phobius details amino acids 992 to 1015 (24 residues), see Phobius details amino acids 1042 to 1061 (20 residues), see Phobius details amino acids 1073 to 1096 (24 residues), see Phobius details PF00873: ACR_tran" amino acids 4 to 515 (512 residues), 463.2 bits, see alignment E=2.6e-142 amino acids 584 to 1097 (514 residues), 370.1 bits, see alignment E=3.4e-114 PF03176: MMPL" amino acids 898 to 1097 (200 residues), 39.1 bits, see alignment E=7.1e-14 PF02355: SecD_SecF" amino acids 941 to 1080 (140 residues), 25.4 bits, see alignment E=1.3e-09

Best Hits

KEGG orthology group: K03296, hydrophobic/amphiphilic exporter-1 (mainly G- bacteria), HAE1 family (inferred from 89% identity to amc:MADE_01076)

Predicted SEED Role

"RND multidrug efflux transporter; Acriflavin resistance protein"

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Search structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

Find the best match in UniProt

Protein Sequence (1127 amino acids)

>MIT1002_02302 Cation efflux system protein CzcA (Alteromonas macleodii MIT1002)
MRIVDIAVKRPVAVSMFTFAVLLFGMVSLGRLSVNLLPDLSYPTLTIRTDYDGAAPGEVE
QLVSKPIEEAIGVVKGVRKVTSTSRAGQSDVVLSFAWGTDMDFASLEVREKLDVLQLPLD
IEKPRLLRFNPSLDPVIKLGLTAQSDTSSLSVAQMKRLRLYAEQQVKRALESVEGVAAVR
VGGGLENEIHILIDQQKASQLSIPITRIIDRVSAENINAAGGRIDNAAQAFLVRTLNQFE
TLSDIENLFIGRFEGRNIQLKDVATVESAYKDRDVVTRFNGNEGIEIAIYKEGDANAVNV
AQKVASRLNEVNNNLPSNYTLSEIYDQSVFIKQAIDNVKSAAVMGGILAMLVLYLFLKDF
WATVIISVSIPVSVIATFNLMYANDISLNMMSLGGIALAVGLLVDNSIVVLENIDRHKKL
KVAGSDNATANEKTTAEATDTEASAASEGTKEVSGAIVASTLTTMAVFVPLIFVEGIAGQ
LFKDQALTVSFALAASLVVALTLIPAMAHKKKKQQLDHEEVFTTPAPTPPTSTFGKVMYY
LTLPIRWVFRLIFVFLPAALVTLVIGAWHIVSKLLSVAFKPLIWVFNKAFDLLASAYEKL
LRVSLKAKALVLATAFILAAGAIMLVPKLGMELIPTLSQGEFSVEVTLPAGSPLARTDAI
ISELAAVAVNNNDGGETKVLRTYAMSGTGSLISAAPNQGGDRWGRLNIVMQPTATASDMD
AVKRALRDHLAFKPQVQATFSEPELFSFASPIQIEIAGYDLNQLQQYGDAIATKLASFNN
FTDVTTSIRDGNPELKIAFHHAKLARLELDASTVSQLIAAKVGGRVATQYSVEDRKVDVL
VRTQENQRDDIASVRAIVVNPGSAQPIPLSAVADVFMSVGPSEITRVGQQRVALVSANLA
KGKLDEAVAVANKVIDETQLPLSLSATVTGQSEDMQSSFRSLQFALALAVFMVYLVMASQ
FESLLHPLLILFAVPLAGAGSVYGLWLTNTPLNVVVFIGLIMLCGIVVNNAIVLVDRINQ
LRRQGVEKDTAILDAAKTRLRPIVMTTLTTVLGLLPMAFGFGEGAEIRTPMAITVIYGLL
FASLLTLILLPVLYSLFDVKKKAPVKDNSRENVGFGDKEAMPKGGVL