Protein Info for MIT1002_02301 in Alteromonas macleodii MIT1002

Annotation: Multidrug transporter MdtA

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 300 350 377 TIGR01730: efflux transporter, RND family, MFP subunit" amino acids 67 to 374 (308 residues), 227.8 bits, see alignment E=8.1e-72 PF16576: HlyD_D23" amino acids 89 to 293 (205 residues), 87.2 bits, see alignment E=2e-28 PF13533: Biotin_lipoyl_2" amino acids 95 to 139 (45 residues), 46.6 bits, see alignment 4.6e-16 PF13437: HlyD_3" amino acids 188 to 291 (104 residues), 56.8 bits, see alignment E=6.9e-19

Best Hits

KEGG orthology group: None (inferred from 88% identity to amc:MADE_01077)

Predicted SEED Role

"Probable Co/Zn/Cd efflux system membrane fusion protein" in subsystem Cobalt-zinc-cadmium resistance

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Search structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

Find the best match in UniProt

Protein Sequence (377 amino acids)

>MIT1002_02301 Multidrug transporter MdtA (Alteromonas macleodii MIT1002)
METTTHSNTSFSPIRSLLPFSPTSLKLLVGSGIVALSLSMTACSDADAINDQANATEVEE
TVFAIPVETQTIVTGDITSTYDTTAILEAREEAFVVARASGIIEKIFVEEGDYVEKGQVL
AQLDKRRYELNLSKALADLAGIESELEKVNKVYSKKLISDDTYDKLTSQFESAKASVRLA
ELDLKEATITAPIDGYIAERNAKVGNLTESFQRERMFHIVQQRNLQGIVYLPENELPNVV
IGQGAMLTVAALGDRSITASVERISPVIDATTGTFKVTLKVPNEDNKLKAGMFTDVSLEY
ATHANATLLPRRALVTIDNNHSVFVVDNGKVKKVDISTGFENNEVVEVINGLNGNEEVVT
AGHQNLKDSAPVEVVNS