Protein Info for MIT1002_02282 in Alteromonas macleodii MIT1002

Annotation: Prolyl endopeptidase precursor

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 300 350 400 450 500 550 600 650 720 signal peptide" amino acids 1 to 21 (21 residues), see Phobius details PF02897: Peptidase_S9_N" amino acids 48 to 447 (400 residues), 364.1 bits, see alignment E=9e-113 PF00326: Peptidase_S9" amino acids 507 to 720 (214 residues), 203.8 bits, see alignment E=2.5e-64

Best Hits

KEGG orthology group: K01322, prolyl oligopeptidase [EC: 3.4.21.26] (inferred from 85% identity to amc:MADE_01001)

Predicted SEED Role

"Prolyl endopeptidase (EC 3.4.21.26)" (EC 3.4.21.26)

Isozymes

No predicted isozymes

Use Curated BLAST to search for 3.4.21.26

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Compare to protein structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

Find the best match in UniProt

Protein Sequence (720 amino acids)

>MIT1002_02282 Prolyl endopeptidase precursor (Alteromonas macleodii MIT1002)
MKKNLIYAAIVAASAGLTLACTSSYIESTSSVQGESQSGGMPKVSDYPETKTVTQQDNYH
GTVVSDPYRWLEEEKSEEVSAWVESQNTLARPYLAELPSRERYKERLTALWDYEKYSTPY
MVNGKLFYSYNDGLQNQYVLYMADGVNGEPEVLIDPNTLSEDGTVSMASTELSPKASFLA
YMLSDGGTDWKTIHVRDTSKKSDLTDTIKGIKFSNIAWLPDESGFFYSRYPQNEAGKYDD
SQTVSIYFHAIGTAQSEDKKVFAFDNKPTWNPYPSVVQDGKTLLISVFEGYQANGVYAKS
LVNDNSELVPVFDKWDGRYDLIGEHDDELFFTSTANAPRGKVIKVDFDGGVKATETVIES
TSDTLSSVSLLGEKLFAQYLKDVKGQVSVFDLNGKKIDEIAFNDIGSVSGFYGSKNADTT
FYKLTGFTNPGQVFAYDVKSGESSLFKSIDTGVNYDDYETKQIFYTSKDGTKVPMFIVHK
KGLKLDGNNKTLLYGYGGFNISLLPRYSVSRMVWVEQGNVLAIANLRGGGEYGQQWHKAG
TKLDKQNVFDDFIAAGEYLVESGYTTPEKMGIQGGSNGGLLVGATLTQRPDLFSAALPAV
GVLDMLRYHTPSANARAWSSDYGLSENKDEFEALYAYSPLHNTKPGTCYPATLVTTGDHD
DRVVPWHSYKFAAQLQADQSCDNPILLRVETRAGHGAGTPTWMQIEGYADQWAFLESALN