Protein Info for MIT1002_02276 in Alteromonas macleodii MIT1002

Annotation: Acyl-CoA dehydrogenase

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 300 350 400 450 500 550 600 transmembrane" amino acids 517 to 538 (22 residues), see Phobius details PF12418: AcylCoA_DH_N" amino acids 5 to 34 (30 residues), 35.1 bits, see alignment (E = 2.8e-12) PF02771: Acyl-CoA_dh_N" amino acids 39 to 157 (119 residues), 24.2 bits, see alignment E=9.6e-09 PF02770: Acyl-CoA_dh_M" amino acids 162 to 269 (108 residues), 50.7 bits, see alignment E=4e-17 PF00441: Acyl-CoA_dh_1" amino acids 285 to 452 (168 residues), 63.4 bits, see alignment E=7e-21 PF12806: Acyl-CoA_dh_C" amino acids 472 to 593 (122 residues), 80.9 bits, see alignment E=2.1e-26

Best Hits

KEGG orthology group: K00248, butyryl-CoA dehydrogenase [EC: 1.3.8.1] (inferred from 95% identity to amc:MADE_01005)

Predicted SEED Role

"Acyl-CoA dehydrogenase (EC 1.3.8.7)" (EC 1.3.8.7)

MetaCyc Pathways

Isozymes

Compare fitness of predicted isozymes for: 1.3.8.7

Use Curated BLAST to search for 1.3.8.1 or 1.3.8.7

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Search structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

Find the best match in UniProt

Protein Sequence (600 amino acids)

>MIT1002_02276 Acyl-CoA dehydrogenase (Alteromonas macleodii MIT1002)
MADQLIPRREMQFQLYEVLNTAALCEKARFEEHNVETFNAVIDMAEKMAEELFLPHNAVA
DKNEPTFDGTKVSMIDDVKVAFDTYRESGFIAGHFDFEDGGMQLPVTVMNACAGYFLAAN
PSSTAYPFLTAAAANVIKHFASEDIKSAFLSKMLAGDFTGTMALTEPHAGSSLADIRTSA
RPQDDGTYRIKGSKIYISGGEHELSDNIVHLVLAKIPGGPAGVKGISLFAVPKYRLDAEG
NPDVRNDVTLAGLIHKMGYRGTTSTALTFGENGDCHGYLIGEPHQGLRYMFMMMNEARIG
VGYGAAMIGYRGYRYSLEYAKDRTQGRAAPNLAPEDEPTPIINHGDVRRMLLAQKAYCEG
GMSLCLYGSMLIDEMETETDSKKRTELSQLLDLLTPVFKAWPSEFGPKANDLAIQILGGA
GYTREYPVEQCWRDNRLNPIHEGTNGIQALDLLGRKLWQHDGKGLQVLLSRVTSDMKRAE
TPRAKALVAKLKPYLDQLGGLIQQAAADLRSDKQPVLLTNASCFLNIFSSCVVSWIWLRQ
ANVAEQTLANGAGEQDVDFYEGKLAAAEYFLNWELPLVSRDIEVLSSREATCNNVKASYF