Protein Info for MIT1002_02208 in Alteromonas macleodii MIT1002

Annotation: Gcv operon repressor

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 187 PF13740: ACT_6" amino acids 4 to 76 (73 residues), 61.2 bits, see alignment E=7.3e-21

Best Hits

KEGG orthology group: K03567, glycine cleavage system transcriptional repressor (inferred from 92% identity to amc:MADE_02138)

Predicted SEED Role

"Glycine cleavage system transcriptional antiactivator GcvR" in subsystem Glycine cleavage system or Orphan regulatory proteins

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Search structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

Find the best match in UniProt

Protein Sequence (187 amino acids)

>MIT1002_02208 Gcv operon repressor (Alteromonas macleodii MIT1002)
MSKHQLIVTILGTDKSGILSEIATTVSEAQCNILDSRQAIYGKEFSLTMIIEGTQSAITK
AECILPSLFQRLDLLSMMKRTSHHEKQNLAHLFNVEFSGEDAAGLIKAVTGFFAERHAMI
SAFRQRTFKDKTSGKDNMRCKFVVSLPSNENVDALESDLMSLFTSLNVTGKVVDKQKKDP
NENVTSW