Protein Info for MIT1002_02145 in Alteromonas macleodii MIT1002

Annotation: NAD-dependent protein deacylase

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

• PF02146: SIR2
  • amino acids 15 to 187 (173 residues), 168.3 bits, E=8.8e-54

Best Hits

Swiss-Prot: 59% identical to NPD_SALTI: NAD-dependent protein deacylase (cobB) from Salmonella typhi

KEGG orthology group: K12410, NAD-dependent deacetylase [EC: 3.5.1.-] (inferred from 85% identity to amc:MADE_02072)

Predicted SEED Role

"NAD-dependent protein deacetylase of SIR2 family" in subsystem Pyruvate metabolism II: acetyl-CoA, acetogenesis from pyruvate or Redox-dependent regulation of nucleus processes

KEGG Metabolic Maps

• 1,4-Dichlorobenzene degradation
• Caprolactam degradation
• Glutathione metabolism
• Lipopolysaccharide biosynthesis
• Lysine biosynthesis
• Nicotinate and nicotinamide metabolism
• Nucleotide sugars metabolism
• Sphingolipid metabolism

Isozymes

Compare fitness of predicted isozymes for: 3.5.1.-

Use Curated BLAST to search for 3.5.1.-

Protein Sequence (241 amino acids)

>MIT1002_02145 NAD-dependent protein deacylase (Alteromonas macleodii MIT1002)
MPSDQSLPNIVILTGAGISAESGLKTFRDNDGLWENHRVEEVATPEAFEQNPSLVYRFYN
ARRAQLQQDDVNPNAAHEALAKLEKAFGSNLMLVTQNVDDLHERGGSQSVYHMHGKLLSA
RCAISQQTFDWSDSFDHTTKCPCCNRVTLRPDIVWFGEMPMYMEEIYDALSKADVFIAIG
TSGNVYPAAGFVQIAKESGAHTIEANLEPGVTNALFDESLTGPASHIVPQWVDQLISKYA
L