Protein Info for MIT1002_02137 in Alteromonas macleodii MIT1002

Annotation: Fumarate and nitrate reduction regulatory protein

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 245 PF00027: cNMP_binding" amino acids 42 to 123 (82 residues), 52.4 bits, see alignment E=6.6e-18 PF13545: HTH_Crp_2" amino acids 159 to 231 (73 residues), 60 bits, see alignment E=2.6e-20 PF00325: Crp" amino acids 184 to 215 (32 residues), 54.2 bits, see alignment 1.4e-18

Best Hits

Swiss-Prot: 61% identical to FNR_YERPE: Fumarate and nitrate reduction regulatory protein (fnr) from Yersinia pestis

KEGG orthology group: K01420, CRP/FNR family transcriptional regulator, anaerobic regulatory protein (inferred from 92% identity to amc:MADE_02063)

Predicted SEED Role

"Fumarate and nitrate reduction regulatory protein" in subsystem Oxidative stress

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Search structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

Find the best match in UniProt

Protein Sequence (245 amino acids)

>MIT1002_02137 Fumarate and nitrate reduction regulatory protein (Alteromonas macleodii MIT1002)
MSKGSQFSIHCQNCSFSHLCLPVALNKTEIESLDDIIERKKPLHKGDTLIQTGDKFRSLF
AVRTGSFKSFVTNTEGEEQITGFHFPGDIIGFDALRENKHQSYTSALETAMVCELPYETL
DEMSVQFPKLRHQIMSFMSAEIKQDHDMIMLLNKRTAEERLLYFISHLSQRFEERGFSHR
EFHLTMTRNEIGNYLGLTIETISRLLSRFQKDNIIKVDGKLITILDFDRLNTKLAALNGP
SVVCG