Protein Info for MIT1002_02134 in Alteromonas macleodii MIT1002

Annotation: putative copper-importing P-type ATPase A

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 300 350 400 450 500 550 600 650 700 750 816 transmembrane" amino acids 182 to 202 (21 residues), see Phobius details amino acids 214 to 235 (22 residues), see Phobius details amino acids 248 to 269 (22 residues), see Phobius details amino acids 275 to 293 (19 residues), see Phobius details amino acids 428 to 449 (22 residues), see Phobius details amino acids 455 to 480 (26 residues), see Phobius details amino acids 771 to 790 (20 residues), see Phobius details amino acids 793 to 814 (22 residues), see Phobius details PF12156: ATPase-cat_bd" amino acids 5 to 90 (86 residues), 89.7 bits, see alignment E=4.2e-29 PF00403: HMA" amino acids 98 to 157 (60 residues), 47.7 bits, see alignment 4.1e-16 TIGR01525: heavy metal translocating P-type ATPase" amino acids 249 to 813 (565 residues), 509.7 bits, see alignment E=2.4e-156 TIGR01494: HAD ATPase, P-type, family IC" amino acids 283 to 545 (263 residues), 133.4 bits, see alignment E=1.6e-42 amino acids 627 to 790 (164 residues), 103 bits, see alignment E=2.8e-33 PF00122: E1-E2_ATPase" amino acids 313 to 488 (176 residues), 166.6 bits, see alignment E=1.1e-52 PF00702: Hydrolase" amino acids 505 to 725 (221 residues), 81.1 bits, see alignment E=3.6e-26 PF08282: Hydrolase_3" amino acids 699 to 745 (47 residues), 28.7 bits, see alignment 2.8e-10

Best Hits

Predicted SEED Role

"Type cbb3 cytochrome oxidase biogenesis protein CcoI; Copper-translocating P-type ATPase (EC 3.6.3.4)" (EC 3.6.3.4)

Isozymes

Compare fitness of predicted isozymes for: 3.6.3.4

Use Curated BLAST to search for 3.6.3.4

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Compare to protein structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

Find the best match in UniProt

Protein Sequence (816 amino acids)

>MIT1002_02134 putative copper-importing P-type ATPase A (Alteromonas macleodii MIT1002)
MARHDCYHCGLPIASSDNGKFTTVILGQQRDMCCPGCLAVAEAIVNNGLEDYYQFRTEPA
QKSDDGILETLDKLKVYDDPSLQEEFVFEEGQDKQIQLTLEGITCAACGWLIEKQLSKVE
GIKQVAVNVQERRALVTWSPFQIKLSQILSTLKRIGYVGSPFHPDEHEASYKREQKTFLK
KLGLAGIMTMQVMMLMTGLYFDWFGAIELETRQYFYWVALTLTTPVVLYSGSNFYMGAAK
ALSAKTVNMDVPVTLAIFGTYIAGIRSTVLEQGEVYFESICMFIFLLLLSRFLEHRSRHR
AAQISANMMQYVPVSATKLNPDGSLTECLAKQLKIDDVVLVKPGETVPIDGVVTDGNAAV
DESMLTGEFNPVRKSNSSPVYGGTVCQDGTLTITVTQTLKNALVNQIVRLQASAMASKPK
AAQIADNFSRYFVTAVLLISALTYGFWAYQGSDEAFWITISVLVATCPCALGLATPSALT
CAMAKLNRQGILLKRADALEQITDIDTIALDKTGTLTKGKFTISNAWYADGVDSNSALSI
ARALESRSEHPIAKAFSDGIAFSENSASSGSANVIDSTVHKVTNFTVTPGGGISGEINDT
LFSMGSAAFSVHESQLKLIEAFPSANVFLTVKGRIMAAYEVKDSLREDTQETLDILAASH
TLAVLSGDTQQNVNALTAPLPISTAKGGLTPEQKYEAVQAMQQSGAKVMMMGDGINDAPV
LASADVAIAVGNATDVAKTAADVILLGDQLLSVPELIRTAHQVKQKIRQNIGWSVGYNVL
ILPFAVSGLLSPWMAVVGMSLSSIIVVTNSTRLLSK