Protein Info for MIT1002_02056 in Alteromonas macleodii MIT1002

Annotation: Cadmium, cobalt and zinc/H(+)-K(+) antiporter

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 295 transmembrane" amino acids 14 to 34 (21 residues), see Phobius details amino acids 80 to 99 (20 residues), see Phobius details amino acids 112 to 133 (22 residues), see Phobius details amino acids 154 to 172 (19 residues), see Phobius details amino acids 178 to 197 (20 residues), see Phobius details TIGR01297: cation diffusion facilitator family transporter" amino acids 14 to 284 (271 residues), 197.7 bits, see alignment E=1.2e-62 PF01545: Cation_efflux" amino acids 17 to 201 (185 residues), 137.1 bits, see alignment E=3.3e-44

Best Hits

KEGG orthology group: K03295, cation efflux system protein, CDF family (inferred from 97% identity to kko:Kkor_1267)

Predicted SEED Role

"Cobalt-zinc-cadmium resistance protein CzcD" in subsystem Cobalt-zinc-cadmium resistance

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Compare to protein structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

Find the best match in UniProt

Protein Sequence (295 amino acids)

>MIT1002_02056 Cadmium, cobalt and zinc/H(+)-K(+) antiporter (Alteromonas macleodii MIT1002)
MHDHSHSHGSNNRIGWAFFLNVTFTIIEFIGGILTNSTAIMADAVHDLGDSLSIGFAWFL
SKVSEKGSNSEFTYGYRRLSLFGALINGLVLIIGSVWVLTEAIPKLLQPEMPIVEGMIAL
AVFGVLVNGFAAYKLSKGKTLNERVLNWHLLEDVLGWVAVLIVSIVLLFVDWPILDPALS
ILFTLYILINVAKNLWHTIRLFLQAIPDKELSKSVYKTLIELKEVDSIHHLHLWSLDGEH
HVLTAHLALQEALSTQQQLELKKSIAERLSKFNLEHTTIELEMTNEQCRDDSQAL