Protein Info for MIT1002_02027 in Alteromonas macleodii MIT1002

Annotation: Malate-2H(+)/Na(+)-lactate antiporter

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 300 350 400 450 491 transmembrane" amino acids 12 to 33 (22 residues), see Phobius details amino acids 39 to 57 (19 residues), see Phobius details amino acids 76 to 97 (22 residues), see Phobius details amino acids 115 to 135 (21 residues), see Phobius details amino acids 143 to 169 (27 residues), see Phobius details amino acids 197 to 219 (23 residues), see Phobius details amino acids 239 to 258 (20 residues), see Phobius details amino acids 264 to 284 (21 residues), see Phobius details amino acids 297 to 315 (19 residues), see Phobius details amino acids 334 to 355 (22 residues), see Phobius details amino acids 377 to 395 (19 residues), see Phobius details amino acids 451 to 471 (21 residues), see Phobius details TIGR00931: Na+/H+ antiporter NhaC" amino acids 8 to 476 (469 residues), 448.2 bits, see alignment E=1.5e-138 PF03553: Na_H_antiporter" amino acids 166 to 473 (308 residues), 211.6 bits, see alignment E=8.5e-67

Best Hits

KEGG orthology group: K03315, Na+:H+ antiporter, NhaC family (inferred from 97% identity to amc:MADE_02004)

Predicted SEED Role

"Na+/H+ antiporter NhaC"

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Compare to protein structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

Find the best match in UniProt

Protein Sequence (491 amino acids)

>MIT1002_02027 Malate-2H(+)/Na(+)-lactate antiporter (Alteromonas macleodii MIT1002)
MTNKEIKTPSLLDAMLPILALVIMMGSAVYLFADSSSYGPNQIALLLAMGLAAIIGMKNG
YSWKTIEKGIVDGISMSLGACLILLAVGSLIGTWMLAGTVPTLIYFGLELLNPSFFYAAA
CLICAVVAMSIGSSWTTAATVGVALMGVSAGMEMSAAITAGAVVSGAYFGDKISPLSETT
NLAPAVAGTDLFEHIRYMLWTTIPSFVIALILFTVLGFSEVGEAKAERIEQMQLLLNESF
DLGWHLLIPLVVLLTLAIKKMPAFPAVFIGALLGGVWAVVFQWDVVTSMASGDDSVNVGA
LKVVWTALFDGVSFSTPDENLNSLLSRGGMSSMLNTIWLIICAMSFGAVLERVGLLKRAV
SAILIGAKSAGDMVSRTILTCFGTNLVTADQYISIVMPGRMYKEEFKKRGLDQLNLSRSL
EDGGTLTSPLIPWNTCGAYMHSVLLVNPFDYVFYAFFNVINPILAVIYAYLGIKILRITP
PHVEVNSKDTV