Protein Info for MIT1002_01953 in Alteromonas macleodii MIT1002

Annotation: Flavin-dependent tryptophan halogenase PrnA

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 300 350 400 450 506 PF04820: Trp_halogenase" amino acids 11 to 466 (456 residues), 624.7 bits, see alignment E=5e-192

Best Hits

KEGG orthology group: K14266, FADH2 O2-dependent halogenase I [EC: 1.14.14.7] (inferred from 99% identity to amc:MADE_01880)

Predicted SEED Role

"Tryptophan halogenase"

Isozymes

Compare fitness of predicted isozymes for: 1.14.14.7

Use Curated BLAST to search for 1.14.14.7

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Compare to protein structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

Find the best match in UniProt

Protein Sequence (506 amino acids)

>MIT1002_01953 Flavin-dependent tryptophan halogenase PrnA (Alteromonas macleodii MIT1002)
MQDPHNKPIKRVVIAGGGTAGWLAASLMKKVLGKAVDITLVESEAIGTVGVGEATIPPIR
LVNQVLGIDEAQFLHDTKATIKLAIRFENWKTKGESYYHTFGAPGKSMAFCHFHHYWVKA
RQQGLKDDLWDFDLNYHAAEAGRFAQINAKDPVVELPFAYHFDASLYAQYLRKLSENMGV
VRKEGKISRVQRFTDSGFIQALHLERGDVVEGDLFVDCTGFKGLLIEEALGAGYDDWSHL
LPCDSAIAVPSERHEKTAPYTRSIAHDAGWQWRIPLQHRNGNGHVYSSRYISDDQACDTL
LSNLDTKPLGDPKLIKFTTGRRRKQWYKNVVAVGLSSGFLEPLESTSIHLIQSAIVRLIQ
LFPHNGFAPSLETEYNKQSELEFEQIRDFLVLHYTVNERTDSAFFNDMRNITLPDSLAHK
IALFKESGNLLREQNDLFLESSWLQVLYGQGITPKDYHGLVDSVPEVQLNQMLTRLLEIK
KEPIAKLPTHDEYINGMVAKYKRAMS