Protein Info for MIT1002_01921 in Alteromonas macleodii MIT1002

Annotation: putative sulfate transport protein CysZ

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 245 transmembrane" amino acids 24 to 44 (21 residues), see Phobius details amino acids 68 to 97 (30 residues), see Phobius details amino acids 144 to 169 (26 residues), see Phobius details amino acids 208 to 236 (29 residues), see Phobius details PF07264: EI24" amino acids 8 to 225 (218 residues), 183.9 bits, see alignment E=2e-58

Best Hits

Swiss-Prot: 53% identical to CYSZ_PECAS: Sulfate transporter CysZ (cysZ) from Pectobacterium atrosepticum (strain SCRI 1043 / ATCC BAA-672)

KEGG orthology group: K06203, CysZ protein (inferred from 96% identity to amc:MADE_01847)

MetaCyc: 51% identical to sulfate:H+ symporter (Escherichia coli K-12 substr. MG1655)
TRANS-RXN0-586

Predicted SEED Role

"Sulfate transporter, CysZ-type" in subsystem Cysteine Biosynthesis

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Compare to protein structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

Find the best match in UniProt

Protein Sequence (245 amino acids)

>MIT1002_01921 putative sulfate transport protein CysZ (Alteromonas macleodii MIT1002)
MSSGGVHYFFEGFSLIKTKGLKRFVFVPLTINLVLFSVAFYFLFGQIEMGIAYVIDLVPE
WLGWIKTAISFFLWPLAVISVLLIFALIFGTLANWIAAPFNGVLSEKVERHLTGQDLGDE
GVMSLVKDIPRTVGRELTKLVWYLPRAIGFLLLFFFLPIIGQVLWFLFNAWMMAIQYCDY
PYDNHKIDFTRMRLHLGEHKGKAMTFGMMVNIFSLIPVVNFIVMPVAICGATSMWVRELK
DTLAK