Protein Info for MIT1002_01868 in Alteromonas macleodii MIT1002

Annotation: Triosephosphate isomerase

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

• PF00121: TIM
  • amino acids 8 to 246 (239 residues), 303.6 bits, E=5.4e-95
• TIGR00419: triose-phosphate isomerase
  • amino acids 9 to 237 (229 residues), 196.7 bits, E=2.5e-62

Best Hits

Swiss-Prot: 53% identical to TPIS_HERAR: Triosephosphate isomerase (tpiA) from Herminiimonas arsenicoxydans

KEGG orthology group: K01803, triosephosphate isomerase (TIM) [EC: 5.3.1.1] (inferred from 86% identity to amc:MADE_01687)

MetaCyc: 47% identical to triosephosphate isomerase subunit (Lactobacillus delbrueckii bulgaricus)
Triose-phosphate isomerase. [EC: 5.3.1.1]

Predicted SEED Role

"Triosephosphate isomerase (EC 5.3.1.1)" in subsystem Calvin-Benson cycle or Glycolysis and Gluconeogenesis or Glycolysis and Gluconeogenesis, including Archaeal enzymes or MLST (EC 5.3.1.1)

MetaCyc Pathways

• superpathway of glycolysis, pyruvate dehydrogenase, TCA, and glyoxylate bypass (23/26 steps found)
• superpathway of glycolysis and the Entner-Doudoroff pathway (16/17 steps found)
• gluconeogenesis I (13/13 steps found)
• superpathway of cytosolic glycolysis (plants), pyruvate dehydrogenase and TCA cycle (19/22 steps found)
• glycolysis II (from fructose 6-phosphate) (11/11 steps found)
• glycolysis III (from glucose) (11/11 steps found)
• glycolysis I (from glucose 6-phosphate) (12/13 steps found)
• homolactic fermentation (11/12 steps found)
• superpathway of anaerobic sucrose degradation (16/19 steps found)
• Calvin-Benson-Bassham cycle (11/13 steps found)
• formaldehyde assimilation III (dihydroxyacetone cycle) (10/12 steps found)
• hexitol fermentation to lactate, formate, ethanol and acetate (15/19 steps found)
• ethene biosynthesis V (engineered) (19/25 steps found)
• glycolysis IV (8/10 steps found)
• 1-butanol autotrophic biosynthesis (engineered) (20/27 steps found)
• gluconeogenesis III (9/12 steps found)
• superpathway of N-acetylneuraminate degradation (16/22 steps found)
• glycolysis VI (from fructose) (8/11 steps found)
• superpathway of hexitol degradation (bacteria) (13/18 steps found)
• glycolysis V (Pyrococcus) (7/10 steps found)
• oxygenic photosynthesis (12/17 steps found)
• photosynthetic 3-hydroxybutanoate biosynthesis (engineered) (18/26 steps found)
• sucrose degradation V (sucrose α-glucosidase) (2/5 steps found)
• glycerol degradation to butanol (9/16 steps found)
• gluconeogenesis II (Methanobacterium thermoautotrophicum) (8/18 steps found)
• Methanobacterium thermoautotrophicum biosynthetic metabolism (21/56 steps found)

KEGG Metabolic Maps

• Carbon fixation in photosynthetic organisms
• Fructose and mannose metabolism
• Glycolysis / Gluconeogenesis
• Inositol phosphate metabolism

Isozymes

No predicted isozymes

Use Curated BLAST to search for 5.3.1.1

Protein Sequence (247 amino acids)

>MIT1002_01868 Triosephosphate isomerase (Alteromonas macleodii MIT1002)
MSKNLRKPFVAGNWKMNGNLALVAEFNQKLANVKADSEIVICAPSLLLHAFETHSFAIGA
QNVSHLNNGAHTGELSVEMLKEAGCGYAIVGHSERREDQGESSELVALKAKQCVSSGVVP
IICVGEPLEVREAGDVESFVGEQLDALVSAMSVDELSKTVIAYEPIWAIGTGKTASPEQA
QEVHEFIRGYFNNVDAQLAQGLRILYGGSVKPDNAETLFAQKDVDGGLIGGASLKAEDFI
SICQAAN