Protein Info for MIT1002_01859 in Alteromonas macleodii MIT1002

Annotation: Lon protease

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 300 350 400 450 500 550 600 650 700 750 798 PF20437: LonC_helical" amino acids 91 to 124 (34 residues), 51.2 bits, see alignment (E = 2e-17) PF13654: AAA_32" amino acids 320 to 451 (132 residues), 171.4 bits, see alignment E=2e-54 PF20436: LonB_AAA-LID" amino acids 480 to 543 (64 residues), 69 bits, see alignment E=5.7e-23 PF05362: Lon_C" amino acids 653 to 759 (107 residues), 42 bits, see alignment E=1.6e-14

Best Hits

KEGG orthology group: None (inferred from 96% identity to amc:MADE_01670)

Predicted SEED Role

"ATP-dependent protease La (EC 3.4.21.53) Type II" in subsystem Proteasome bacterial or Proteolysis in bacteria, ATP-dependent (EC 3.4.21.53)

Isozymes

Compare fitness of predicted isozymes for: 3.4.21.53

Use Curated BLAST to search for 3.4.21.53

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Search structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

Find the best match in UniProt

Protein Sequence (798 amino acids)

>MIT1002_01859 Lon protease (Alteromonas macleodii MIT1002)
MSVDSKLYALDVDALSPTINRRAINSALKDDEALNATFIGQERAREALTFGLGINTKGYN
LYVMGEPATGRFTLVKDYIERQVAQLPAPDDCCYINNFDEEREPVALKFPPGGGKAFHKD
MAALIDDVIDSLPIAFDNPGYQRRRASISREFEQKYDAAIDAVERYAQANDVALYEEGGS
ITFSPIVNGKPISDTEFASLTDAQREGFYTLIDELENRLSEGLLSLPTWKRENSERLREL
DKKTAEQGIKPLLKVLEHKYASELGVMKYLKQLKTALVNAILVIHSEEQKEEKSDDFDKK
IFLEEQFLPNVLVSNKLDDAAPVIYEPNPTYQNLFGKIEYTNIHGSVFTNYRMIQPGALH
RANGGYLLLDVDQLIEQPFVWDTLKLAIKSQRLRMDLPQQDVGMVNNITLNPQPIDLNVK
IVLLGSRDLYYTLQDYDDEFDELFRVLVDFDLEIPVTRQALFDFVGKVRAHLIQLGLKGI
TANAMCRLVEYSLRMAEHKEKLSAHFAEVIELVNEAYYFCQKSNADTLELDHLKTALSAK
KRRTGRVSQTLLNDIKEGHVLIATEGKAVGKVNGLTVLDIGDTAFGTPARITSTVFAGAS
GVVDIEREVELGQPIHSKGVMLLNGYLGNKYAQHFPLTLSANIALEQSYGHIDGDSASLG
ELVALISALTEIPCLQTLAITGSINQYGEVQAVGGVNEKIEGFFDLCQHRGLTGTQGVII
PKSNAINLVLDATVIDAVKKGLFHIYTVETVDDALSILMEQEAGKISSKGRYPKNSINYH
AVNRLYNIALIVNGGDGE