Protein Info for MIT1002_01819 in Alteromonas macleodii MIT1002

Annotation: Membrane-bound aldehyde dehydrogenase [pyrroloquinoline-quinone] precursor

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 300 350 400 450 500 550 600 650 700 753 signal peptide" amino acids 1 to 40 (40 residues), see Phobius details PF10518: TAT_signal" amino acids 8 to 25 (18 residues), 23.9 bits, see alignment (E = 4.3e-09) PF20256: MoCoBD_2" amino acids 48 to 195 (148 residues), 56 bits, see alignment E=7.1e-19 amino acids 616 to 701 (86 residues), 59.5 bits, see alignment E=6e-20 PF02738: MoCoBD_1" amino acids 321 to 548 (228 residues), 102.7 bits, see alignment E=2.8e-33

Best Hits

KEGG orthology group: K07303, isoquinoline 1-oxidoreductase, beta subunit [EC: 1.3.99.16] (inferred from 95% identity to amc:MADE_02379)

Predicted SEED Role

"Isoquinoline 1-oxidoreductase beta subunit (EC 1.3.99.16)" in subsystem N-heterocyclic aromatic compound degradation (EC 1.3.99.16)

Isozymes

Compare fitness of predicted isozymes for: 1.3.99.16

Use Curated BLAST to search for 1.3.99.16

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Search structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

Find the best match in UniProt

Protein Sequence (753 amino acids)

>MIT1002_01819 Membrane-bound aldehyde dehydrogenase [pyrroloquinoline-quinone] precursor (Alteromonas macleodii MIT1002)
MSENTYFDMNRRSFLKSTAAAGALVLGTYFMGGAPRAMAGVLAKPAENAKRANLFIALRP
DGMVEVTCHRSEMGQQIRTAIAQIVADEMEAAWDKVIVIQGKGDPKYGDQNTDGSRSIRF
NMQRLREMGASVRYMMQHAAAKRWGVEPSTCVAEQHVVTHTSGKTLAYKDLIDDALTITP
PEADKLKLKERKEWRYINTGMAHIDLQDIVTGKATFAADVREPKALVAIIERPPVVGGKV
KSFNADKAKAVNGVVDVIEIPAPKGAPQFQPKGGLAIIANNTWAAWQGRKALDVTWDDGA
NGGYNSANFKEQLLNTVNAPQALVREKGDALSVLEKASDKLVADYYVPHLAQAPMEPPCA
TAMYYKDRVDVWAATQNPQADMETVGAMVGMDKEKINVHVTMLGGAFGRKSKPDFSAEAA
FLSMKTGKPIRVQWTREDDIQHGFYHAVSAQHVEAALDENGKIDAYLHRTAFSPIASTFQ
EGANAPFSFELDLGFTDNPILTPNMKLERGEAPAKARIGWMRSVSNIFHAFAVQSFINEA
AHKAGKDAKDYLLEVIGPDRIIDVTDQKAEYQNYWGDKSVYPLDTGRLRNVIEKVSDMAG
WGRNMPKGRGLGIAAHRSFLTYVATVVEVEVSDAGDLSVIKSWVAIDAGTVVNTDTVKNQ
TQGGSVYGITTAISDGITFDKGRVQQSNFHNYRVPRMSDSPLEVEVEVIESDAPPAGVGE
PATPVYAPALCNAIFAACGKRIRQLPIGNQLKA