Protein Info for MIT1002_01643 in Alteromonas macleodii MIT1002

Annotation: Beta-hexosaminidase

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

• PF00933: Glyco_hydro_3
  • amino acids 14 to 297 (284 residues), 257.9 bits, E=8e-81

Best Hits

Swiss-Prot: 59% identical to NAGZ_TOLAT: Beta-hexosaminidase (nagZ) from Tolumonas auensis (strain DSM 9187 / TA4)

KEGG orthology group: K01207, beta-N-acetylhexosaminidase [EC: 3.2.1.52] (inferred from 88% identity to amc:MADE_02440)

Predicted SEED Role

"Beta N-acetyl-glucosaminidase (EC 3.2.1.52)" (EC 3.2.1.52)

MetaCyc Pathways

• peptidoglycan recycling I (10/14 steps found)
• chitin degradation II (Vibrio) (2/6 steps found)
• chitin degradation III (Serratia) (2/7 steps found)
• peptidoglycan recycling II (3/10 steps found)

KEGG Metabolic Maps

• Aminosugars metabolism
• Glycosaminoglycan degradation
• Glycosphingolipid biosynthesis - ganglio series
• Glycosphingolipid biosynthesis - globo series
• Nucleotide sugars metabolism
• Other glycan degradation

Isozymes

Compare fitness of predicted isozymes for: 3.2.1.52

Use Curated BLAST to search for 3.2.1.52

Protein Sequence (340 amino acids)

>MIT1002_01643 Beta-hexosaminidase (Alteromonas macleodii MIT1002)
MGPLMLDCQAEELLPEEKEKLTHPVVGGVILFSRNYHDKRQLSALVQDIRRFAKQPVLIA
VDHEGGRVQRFREGFTAIPAMGDILRQSEHQDESAAYAKACGLVLAYELKTLDIDFSFAP
VLDINGVSQVIGDRAFSDNADDVIRLAAHLIQGLKAVNMPAIGKHFPGHGSVAPDSHIAL
PVDEREFDEMRSTDMVVFERLIERALLDGVMPAHVIYNQVCDKPAGFSTKWLQDILKQDL
GFGGAVFSDDLSMHGASVAGSYVERAEAALEAGCDMVLACNNPQGADTILDGLETRFANL
SNNDLQKQERVMALYDRVMPAGLKDKYDSGVELVKRLSER