Protein Info for MIT1002_01618 in Alteromonas macleodii MIT1002

Annotation: Cyclic di-GMP phosphodiesterase Gmr

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 300 350 400 450 500 550 600 645 signal peptide" amino acids 1 to 21 (21 residues), see Phobius details transmembrane" amino acids 154 to 175 (22 residues), see Phobius details PF16448: LapD_MoxY_N" amino acids 23 to 147 (125 residues), 135.6 bits, see alignment E=1.3e-43 TIGR00254: diguanylate cyclase (GGDEF) domain" amino acids 236 to 391 (156 residues), 51.2 bits, see alignment E=5.8e-18 PF00990: GGDEF" amino acids 238 to 389 (152 residues), 71.5 bits, see alignment E=1.1e-23 PF00563: EAL" amino acids 413 to 640 (228 residues), 171.1 bits, see alignment E=4e-54

Best Hits

KEGG orthology group: None (inferred from 80% identity to amc:MADE_02471)

Predicted SEED Role

"GGDEF and EAL domain proteins"

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Compare to protein structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

Find the best match in UniProt

Protein Sequence (645 amino acids)

>MIT1002_01618 Cyclic di-GMP phosphodiesterase Gmr (Alteromonas macleodii MIT1002)
MRLSTQLSTSLAIFLVLVFAGSFIINVKLTREYVNEQLATHAQDTATSLGLSITPYIGEP
NGIIVAETMVNAIFDRGFYQYITVSDMEGNLLIERKNPNTQDSVPAWFTNLVEVTPPVQR
TELNDGWTLAGELTVQSHPGLANETLYESVKQSAFMFFAAFVVAYIALLFIITAITKPLR
IVVHKINDIQNQKFSQINYKPFTQELTFITQAVNKLSSSVEGMFKELSQKAEHFKAQAYE
DSLTGVQNRSAFTRHMNALLSSTAHSDEGYIVIIRLAHLNAINTSLGAQEGDNYVTSVAN
ILKQFSKESAETTHLFRLSGADFALVTEAISKRECSNKIEDLSETLVHCNPLKDGIRSVW
MGVAQFSDKQSFSEIMENADSALMAATKQANGWQFASELSHLHSNTAWRERLNVILEQQY
ADMLIQPVMSIAENTPSYFEAFARFKDKESGSVIPMSQLIPASERLNLIPEVDKLVATLV
FKKLSQAKCDVAINIANASLANSHFRTWLVAQLNQNTALCTKLVFEFEDSALIHHKDDTI
SFCKTLMTLGCRVTIEHFGENLASLAGLRAIQPHFVKISGKLTKDIHTDKDNQLFVSSLL
SIARGLNINVIAELVENEAESVALTQLDVAYQQGFYFAKPTLWQN