Protein Info for MIT1002_01574 in Alteromonas macleodii MIT1002

Annotation: Xanthine dehydrogenase molybdenum-binding subunit

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

• TIGR02965: xanthine dehydrogenase, molybdopterin binding subunit
  • amino acids 20 to 779 (760 residues), 1166 bits, E=0
• PF01315: Ald_Xan_dh_C
  • amino acids 34 to 138 (105 residues), 74.6 bits, E=1.2e-24
• PF02738: MoCoBD_1
  • amino acids 165 to 395 (231 residues), 242.9 bits, E=4.2e-76
• PF20256: MoCoBD_2
  • amino acids 422 to 708 (287 residues), 330 bits, E=2.2e-102

Best Hits

KEGG orthology group: K13482, xanthine dehydrogenase large subunit [EC: 1.17.1.4] (inferred from 88% identity to amc:MADE_02516)

Predicted SEED Role

"Xanthine dehydrogenase, molybdenum binding subunit (EC 1.17.1.4)" in subsystem Purine Utilization (EC 1.17.1.4)

MetaCyc Pathways

• adenosine nucleotides degradation II (5/5 steps found)
• purine nucleotides degradation I (plants) (10/12 steps found)
• adenosine nucleotides degradation I (7/8 steps found)
• guanosine nucleotides degradation II (4/4 steps found)
• purine nucleotides degradation II (aerobic) (9/11 steps found)
• superpathway of guanosine nucleotides degradation (plants) (5/6 steps found)
• guanosine nucleotides degradation I (3/4 steps found)
• guanosine nucleotides degradation III (3/4 steps found)
• inosine 5'-phosphate degradation (3/4 steps found)
• ureide biosynthesis (5/7 steps found)
• superpathway of purines degradation in plants (12/18 steps found)
• purine nucleobases degradation II (anaerobic) (16/24 steps found)
• caffeine degradation III (bacteria, via demethylation) (1/7 steps found)
• theophylline degradation (1/9 steps found)
• caffeine degradation IV (bacteria, via demethylation and oxidation) (1/10 steps found)

KEGG Metabolic Maps

• Purine metabolism

Isozymes

Compare fitness of predicted isozymes for: 1.17.1.4

Use Curated BLAST to search for 1.17.1.4

Protein Sequence (788 amino acids)

>MIT1002_01574 Xanthine dehydrogenase molybdenum-binding subunit (Alteromonas macleodii MIT1002)
MRKLIDAPNPLQQNDKQSVVHVSKKHESATRQVQGSANYVDDVIEPQSTLYAAVGVSQCA
KGTINSINLDAVRQSEGVVDVITIDDVPGHKDIGPVFEGDPLLANGEIKFFGQPVFAVLA
TSINLARQAALKGKVEVSEAKPILSAEAAHQQQTFVRPLHRFGQHTDRVESTFEKAIHQA
HGTLSIGGQEHMYLEGQVSLAIPDEEDRMKIYTSSQHPSEVQKLVAEVLDVKLHRVMVDM
RRMGGGFGGKETQAAQWACIAALLASRNQCAVKLRLPRFTDMHVTGKRHPFENEFDVAFD
GTGKIEATRMTINGICGHSPDLSDAIVDRAMFHADNGYFLGDSDIVGHRLQTNMVSHTAY
RGFGGPQGMIMAEAVIDKIARAIGSDPLSVRKRNLYGPTTGSFTPYGMKVEHNLLPDMIA
ELEETAQYWQRREAIAAFNRESPVIKKGLALTPVKFGISFTAKHLNQAGALVHIYTDGSI
QVNHGGTEMGQGLHTKIGQIAANEFGLDLDMIEVTATRTDKVPNTSPTAASSGTDLNGKA
VQNACITLKSRLAECFAKSLGLEDRAGDVLFINGHVVLDEHKITFTELVQQAYFARVSLS
SGGFYKTPKLQYNRDTGEGRPFFYFAYGVSMSEVSVDTLTGEYTVDKVNVLHDVGNSLNP
AIDIGQIEGAFIQGMGWLTTEDLKWNEAGKLISENMATYKIPAIGDTPKEFNVKLFGRKN
AEDSIYHSKAVGEPPFMLAISVWCALKDAISSLSGYTVDPQLDTPATPERVLNAVSAMQQ
SSSRGGVL