Protein Info for MIT1002_01366 in Alteromonas macleodii MIT1002

Annotation: Diguanylate cyclase DosC

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 300 371 transmembrane" amino acids 25 to 47 (23 residues), see Phobius details amino acids 53 to 71 (19 residues), see Phobius details amino acids 83 to 102 (20 residues), see Phobius details amino acids 121 to 147 (27 residues), see Phobius details amino acids 160 to 180 (21 residues), see Phobius details PF20966: MASE6" amino acids 24 to 185 (162 residues), 28.2 bits, see alignment E=1.8e-10 TIGR00254: diguanylate cyclase (GGDEF) domain" amino acids 197 to 357 (161 residues), 152 bits, see alignment E=6.4e-49 PF00990: GGDEF" amino acids 200 to 355 (156 residues), 144.6 bits, see alignment E=2.4e-46

Best Hits

KEGG orthology group: None (inferred from 82% identity to amc:MADE_02658)

Predicted SEED Role

"GGDEF domain protein"

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Search structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

Find the best match in UniProt

Protein Sequence (371 amino acids)

>MIT1002_01366 Diguanylate cyclase DosC (Alteromonas macleodii MIT1002)
MFGSLKQYVFSGVSRHYKDETNRRIMVVNLFAAVGMSITLLLGSRAFIDGEYSLSTTLFT
ASVVFAISQRLQVRFASAKARTWSITLLIICLMVLTLLLLITGGKDNTGPLWIYLVPPVT
MFFAGFVRGLIALIAFTLVSAIVLFGFNDASFVANYTYAFKTRLLYSFFTVSFLSAFYEY
SRQKSYDTALYLSEQFERQAKHDHLTQLLNRRGAQQCLEREYAGMLRSKRKFSVALADID
RFKSINDTLGHEQGDEVLRQISKVFSSRLRGQDILARWGGEEFMFIFTDTDEAGAVNALE
NIRDILNNAPLNINGSEIHVTSSFGVSEVNPDIDISCAVRRADQALYYAKDNGRDCVCEF
SALSSPSFSEN