Protein Info for MIT1002_01320 in Alteromonas macleodii MIT1002

Annotation: Alkaline phosphatase synthesis transcriptional regulatory protein PhoP

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 300 350 400 450 500 558 PF00072: Response_reg" amino acids 3 to 116 (114 residues), 92.8 bits, see alignment E=2.3e-30 PF07228: SpoIIE" amino acids 189 to 379 (191 residues), 112.6 bits, see alignment E=3.4e-36

Best Hits

KEGG orthology group: None (inferred from 82% identity to amc:MADE_01717)

Predicted SEED Role

"Serine phosphatase RsbU, regulator of sigma subunit" in subsystem SigmaB stress responce regulation

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Compare to protein structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

Find the best match in UniProt

Protein Sequence (558 amino acids)

>MIT1002_01320 Alkaline phosphatase synthesis transcriptional regulatory protein PhoP (Alteromonas macleodii MIT1002)
MKILIVDDEAINRTLLTNMLYNAGYKECIEAVDGVEAIKKFTHEKPDLVLLDVVMPGLSG
FDVAPKIRKLAKGPYLPILFITALEDKESLVRCLEVGGNDFATKPFDRHILIAKIRAHLK
IRALSEHIEQQNKALRLFNQRVAREHAIVEHIFSHAIVNRPEVMAHFDCFLKPAETFNGD
LFLCESSPSGGIYFVVGDFTGHGLASAIGALPVTRAFQELSQQGVSISEIISELNRILIK
FLPSDMFMAAVVGEINAGGNRINLWQGGMPAVIVPAKTDLALRCIPSRHMALGILDEHEL
NTDCDTIQLGCNEQLVICSDGLIESTNQEGEMLLEEGLVRIVKEQMQTHGKIESNSLFLK
AKEHCAASSFHDDVTLVVFTSQPIKTPVSPKMDFGLPSVHEVALDAQHLKQPDILQRVLQ
LAGQCEGIQAVRSIIYTVLSELFNNALEHGILKLDSKLKADSTGFHQYYENREASLKALS
HGRINIRIESLPLKGKVLIAVEDSGEGFEWNKASTVGRRHSVHDESFGRGLPLLHALCER
VWFENGGSKVICLLDTKI