Protein Info for MIT1002_01229 in Alteromonas macleodii MIT1002

Annotation: Chorismate synthase

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

• TIGR00033: chorismate synthase
  • amino acids 10 to 350 (341 residues), 471.5 bits, E=7.8e-146
• PF01264: Chorismate_synt
  • amino acids 10 to 345 (336 residues), 466.5 bits, E=1.8e-144

Best Hits

Swiss-Prot: 99% identical to AROC_ALTMD: Chorismate synthase (aroC) from Alteromonas mediterranea (strain DSM 17117 / CIP 110805 / LMG 28347 / Deep ecotype)

KEGG orthology group: K01736, chorismate synthase [EC: 4.2.3.5] (inferred from 99% identity to amc:MADE_02755)

MetaCyc: 75% identical to chorismate synthase (Escherichia coli K-12 substr. MG1655)
Chorismate synthase. [EC: 4.2.3.5]

Predicted SEED Role

"Chorismate synthase (EC 4.2.3.5)" in subsystem Chorismate Synthesis or Common Pathway For Synthesis of Aromatic Compounds (DAHP synthase to chorismate) (EC 4.2.3.5)

MetaCyc Pathways

• superpathway of aromatic amino acid biosynthesis (18/18 steps found)
• superpathway of L-tryptophan biosynthesis (13/13 steps found)
• superpathway of L-phenylalanine biosynthesis (10/10 steps found)
• superpathway of L-tyrosine biosynthesis (10/10 steps found)
• chorismate biosynthesis I (7/7 steps found)
• chorismate biosynthesis from 3-dehydroquinate (5/5 steps found)
• superpathway of chorismate metabolism (42/59 steps found)
• chorismate biosynthesis II (archaea) (8/12 steps found)

KEGG Metabolic Maps

• Biosynthesis of alkaloids derived from shikimate pathway
• Biosynthesis of phenylpropanoids
• Biosynthesis of plant hormones
• Phenylalanine, tyrosine and tryptophan biosynthesis

Isozymes

No predicted isozymes

Use Curated BLAST to search for 4.2.3.5

Protein Sequence (365 amino acids)

>MIT1002_01229 Chorismate synthase (Alteromonas macleodii MIT1002)
MSGNSFGKLFTVTTFGESHGIAIGGVVDGCPPGLEITEEDLQVDLDRRKPGTSRYTTARR
EDDEVQILSGVFEGKTTGTSIGLLIKNKDQRSQDYGNIKDRFRPGHADYTYDQKYGSRDY
RGGGRSSARETAIRVAAGGIAKKYLKEVHGIEVLGYLSQLGPVTVDKVDHSVTNTNPFFC
PDESKLDALDEYMRDLKKSGDSIGAKVSVVAKNVPVGLGEPVFDRLDAEIAHAMMGINAV
KGVEIGDGFDVINQKGSEHRDTLTPDGFTSNHAGGVLGGISTGQDIEVHMALKPTSSISV
PGKTINKDNEEIDIVTKGRHDPCVGIRAVPIAEAMLALVLMDHLLRHRAQNAGVLSTTKP
IAGQA