Protein Info for MIT1002_01189 in Alteromonas macleodii MIT1002

Annotation: Transcriptional regulatory protein YehT

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 242 PF00072: Response_reg" amino acids 10 to 117 (108 residues), 82.5 bits, see alignment E=2.4e-27 PF04397: LytTR" amino acids 148 to 240 (93 residues), 75.3 bits, see alignment E=3.8e-25

Best Hits

Swiss-Prot: 61% identical to Y503_VIBVU: Uncharacterized response regulatory protein VV1_0503 (VV1_0503) from Vibrio vulnificus (strain CMCP6)

KEGG orthology group: K02477, two-component system, LytT family, response regulator (inferred from 61% identity to vvy:VV0691)

Predicted SEED Role

"FIG001014_Response regulator of the LytR/AlgR family"

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Compare to protein structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

Find the best match in UniProt

Protein Sequence (242 amino acids)

>MIT1002_01189 Transcriptional regulatory protein YehT (Alteromonas macleodii MIT1002)
MTKNSAFRALVIDDEPLAREELCQLLNETNEVHVLGEAANAIEGLALIKQHRPDVIFLDI
EMPQLSGLDMLAMLDLDTMPYVVLVTAFEQYALQAFEDNAFDYLLKPVEPERLDKTLARL
KKRTQPQTDIDAIASPTLVHIPCVGHQRILLLPESDIQFAYSDVAGVHVRSLEQQADTQL
TLKILEERTALVRCHRQYLVRLSCVAEIKLLDNGLATLLMKTGDSVPVSRRYLKKLKSLL
TL