Protein Info for MIT1002_01187 in Alteromonas macleodii MIT1002

Annotation: Multidrug resistance protein MdtN

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 300 357 transmembrane" amino acids 12 to 31 (20 residues), see Phobius details PF16576: HlyD_D23" amino acids 46 to 274 (229 residues), 50.6 bits, see alignment E=3.1e-17 PF13533: Biotin_lipoyl_2" amino acids 47 to 91 (45 residues), 45.4 bits, see alignment 1.1e-15 PF13437: HlyD_3" amino acids 202 to 279 (78 residues), 29.7 bits, see alignment E=1.8e-10

Best Hits

KEGG orthology group: None (inferred from 75% identity to amc:MADE_02789)

Predicted SEED Role

"putative secretion protein"

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Search structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

Find the best match in UniProt

Protein Sequence (357 amino acids)

>MIT1002_01187 Multidrug resistance protein MdtN (Alteromonas macleodii MIT1002)
MSQRTPDQEFARYIKLALVAFAICFIYFIIADIRMPMTPQARVYHQVTQISPQINGPINE
VLVKNNQTVKEGQVLFVIDETPYLIALEKAQIDLANVELENAQIDAKAEAIRAKIDAASA
VYDERNSEFQRLNSLVQTKAVSQQNVDKAYAQLKSAEAEISALEADLNQQVVARGKQGDK
NLKYLEAVNAVKRAELNLAYTKIKAPHDGIMANMQVTQGTYAKQSTPLASVVDNTLDVVA
DFREKSLANVKEGIRANVVFDALPGKVFEAKVEEFEAGVSDGQLAANGTLASVEKSNRWV
RDAQRQRVHIKLEEQEISLSHLTSGARATVQIVPDNPIESVAANIQIHFISLLHFIY