Protein Info for MIT1002_01147 in Alteromonas macleodii MIT1002

Annotation: Transcriptional regulatory protein TyrR

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 300 350 400 450 518 PF00989: PAS" amino acids 81 to 128 (48 residues), 29.5 bits, see alignment 2e-10 PF00158: Sigma54_activat" amino acids 207 to 371 (165 residues), 206.3 bits, see alignment E=8.1e-65 PF14532: Sigma54_activ_2" amino acids 209 to 376 (168 residues), 87.7 bits, see alignment E=2.6e-28 PF18024: HTH_50" amino acids 464 to 512 (49 residues), 70.3 bits, see alignment 2.7e-23 TIGR04381: TyrR family helix-turn-helix domain" amino acids 465 to 513 (49 residues), 95.7 bits, see alignment 6.1e-32

Best Hits

Swiss-Prot: 49% identical to TYRR_ENTAG: Transcriptional regulatory protein TyrR (tyrR) from Enterobacter agglomerans

KEGG orthology group: K03721, transcriptional regulator of aroF, aroG, tyrA and aromatic amino acid transport (inferred from 98% identity to amc:MADE_02829)

Predicted SEED Role

"Transcriptional repressor protein TyrR" in subsystem Common Pathway For Synthesis of Aromatic Compounds (DAHP synthase to chorismate) or Phenylalanine and Tyrosine Branches from Chorismate

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Search structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

Find the best match in UniProt

Protein Sequence (518 amino acids)

>MIT1002_01147 Transcriptional regulatory protein TyrR (Alteromonas macleodii MIT1002)
MRLEISCQDRLGITQDVLDILVTKEIDLRGIEIDPAGKIFLNFPNIEFADFQHLMPQIRR
IDGIDDVKTTLFMPGEREKNQLSAILRTLPDPVFSIDAKGNILLCNEAVCAGLEIPSSEI
EGIEIGEVVKGFNFTKWMDGKSPGPQSSKVKFIQQDYLADMLPITVPDGEQNMIMAGAVV
ILKSEMRLGQQFTAFHQSPTDSFDRFVTQSPFMKRVVHEAKRIADLDAPILIFGETGTGK
EMIARACHQSSRRSEGAFLALNCASLPDSVAETELFGYAAGAFNQPNAKVGLLEQAKGGT
LLLDEIADMSSQLQAKLLRVLEDGEFRRVGDSEPVKVDVRFICTTCRDLGQLVEEGRFRK
ELYYRLNVLSLVMPSLKDRRQDIVPLAESFIVQHSTKLGRRPAKLSKSCVDFLQQYPWPG
NVRQLQNALYRALSLLDGKEITKEDIQLPSCAPSVTYIDENFDGTLDEEVKKFEKDLLKR
LYPSYPSTRQLAKKLGLSHTAIANKLREYGINKATVKL