Protein Info for MIT1002_01022 in Alteromonas macleodii MIT1002

Annotation: NEM-activable K(+)/H(+) antiporter

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 300 350 400 450 500 550 600 655 transmembrane" amino acids 6 to 23 (18 residues), see Phobius details amino acids 30 to 49 (20 residues), see Phobius details amino acids 55 to 74 (20 residues), see Phobius details amino acids 84 to 107 (24 residues), see Phobius details amino acids 113 to 133 (21 residues), see Phobius details amino acids 146 to 169 (24 residues), see Phobius details amino acids 176 to 202 (27 residues), see Phobius details amino acids 217 to 236 (20 residues), see Phobius details amino acids 241 to 258 (18 residues), see Phobius details amino acids 270 to 289 (20 residues), see Phobius details amino acids 295 to 317 (23 residues), see Phobius details amino acids 329 to 350 (22 residues), see Phobius details amino acids 357 to 374 (18 residues), see Phobius details PF00999: Na_H_Exchanger" amino acids 13 to 373 (361 residues), 199.2 bits, see alignment E=1.5e-62 PF02254: TrkA_N" amino acids 407 to 520 (114 residues), 80.8 bits, see alignment E=1.5e-26 PF02080: TrkA_C" amino acids 583 to 651 (69 residues), 45.3 bits, see alignment E=9.8e-16

Best Hits

KEGG orthology group: K03455, monovalent cation:H+ antiporter-2, CPA2 family (inferred from 94% identity to amc:MADE_01391)

Predicted SEED Role

"Glutathione-regulated potassium-efflux system protein KefB" in subsystem Glutathione-regulated potassium-efflux system and associated functions

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Compare to protein structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

Find the best match in UniProt

Protein Sequence (655 amino acids)

>MIT1002_01022 NEM-activable K(+)/H(+) antiporter (Alteromonas macleodii MIT1002)
MGTSFLNIVILMFISVCAVALFKRIHLPPILAYLFAGVLAGPQLLSVFAHPEEMHLLAEV
GIVFLLFSLGLEFSLPKLLAMRSLVFGVGLGQMVFTTAVFTCVPLFLGIPISASIIIGGT
LALSSTAIVIKQATEMGILNNRRTQLAVSILLFQDLAVVPFLIAIPLLAQTGEVSIALAL
GEALLKGVFVIAFLMSVGKWLLPWVFREVARTRTDELFVLTTILIALLAGGLTYYFGLSM
ALGAFLAGMMLGESQYKYQLEADIRPFRDILMGLFFVTVGMQLELTVLWNSLFEIVFGVF
ALMIVKVILVRGASLLVKTEAIDGWSAGVKLCQIGEFSFVIAALATTHGVLTSEQSSLIV
CMGVISMALTPWLMNNSVTIARRIVNKDISFDDNVSFGNAEPLTNHVIICGFGRVGQSVA
RMLKMEGIHFVAIDMDPVRVHESRNAGEPVIFGDASQKDILINANAEGAKLVLVTFDQVD
KAKQVITQTRSITSTTDVMVRTKRDYQLESLYSAGANQVVPELQEGSLMLVSQVLHYAGV
PMSRILKRVRAERKGRYDHMHGFYPGETTEITYGTEDKLEFIHAVVLSEHASCIGKTIKD
IDFSRMRVAIKGLRRDGNEVKDPDQDAILQAHDVLVIAGKPRRVERAERKLLEGS