Protein Info for MIT1002_01018 in Alteromonas macleodii MIT1002

Annotation: DNA polymerase III subunit alpha

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 100 200 300 400 500 600 700 800 900 1000 1100 1154 TIGR00594: DNA polymerase III, alpha subunit" amino acids 5 to 1025 (1021 residues), 1378.5 bits, see alignment E=0 PF02811: PHP" amino acids 7 to 171 (165 residues), 153.8 bits, see alignment E=1.6e-48 PF07733: DNA_pol3_alpha" amino acids 290 to 557 (268 residues), 352.9 bits, see alignment E=3.9e-109 PF17657: DNA_pol3_finger" amino acids 560 to 730 (171 residues), 232.8 bits, see alignment E=4.4e-73 PF14579: HHH_6" amino acids 803 to 893 (91 residues), 99 bits, see alignment E=4.5e-32 PF01336: tRNA_anti-codon" amino acids 996 to 1065 (70 residues), 36.9 bits, see alignment 8.5e-13 PF20914: DNA_pol_IIIA_C" amino acids 1094 to 1145 (52 residues), 45.2 bits, see alignment (E = 2e-15)

Best Hits

Swiss-Prot: 71% identical to DPO3A_VIBCH: DNA polymerase III subunit alpha (dnaE) from Vibrio cholerae serotype O1 (strain ATCC 39315 / El Tor Inaba N16961)

KEGG orthology group: K02337, DNA polymerase III subunit alpha [EC: 2.7.7.7] (inferred from 97% identity to amc:MADE_01387)

MetaCyc: 70% identical to DNA polymerase III subunit alpha (Escherichia coli K-12 substr. MG1655)
DNA-directed DNA polymerase. [EC: 2.7.7.7]

Predicted SEED Role

"DNA polymerase III alpha subunit (EC 2.7.7.7)" in subsystem DNA-replication (EC 2.7.7.7)

KEGG Metabolic Maps

Isozymes

Compare fitness of predicted isozymes for: 2.7.7.7

Use Curated BLAST to search for 2.7.7.7

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Compare to protein structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

Find the best match in UniProt

Protein Sequence (1154 amino acids)

>MIT1002_01018 DNA polymerase III subunit alpha (Alteromonas macleodii MIT1002)
MSSPFIHLRVHSDFSMMDGLNKVKPILGKVAALGMPAVAITDQMNMCGLVKFYSEAHNLG
IKPIIGTDFWVTNEVFGDEPFRLTLIAMNNEGYKNITILISKAYLRGHLSHRAVIDQEWL
AEHSEGVIALSGAQHGDVGVGLMKNNAKILDSALEFYQTHFPDRFYLELIRTGRQGEEDY
LHLAVELAEQRGLPVVATNEVCFIDREGFDAHEIRVCIHDGYTLDDNRRPKRYSDQQYLR
TAEEMVELFSDIPEAIENTVEIAKRCNVTVRLNEYFLPQFPTGGMTTEDFLVKVSEEGLE
ERLEFLFPDEEVRKAKRPEYDDRLRIELEVINQMGFPGYFLIVMEFIQWSKDNGIPVGPG
RGSGAGSLVAYALKITDLDPLEFDLLFERFLNPERVSMPDFDVDFCMDRRDEVIDHVAEL
YGRQAVSQIITFGTMAAKAVVRDVGRVLGHPYGFVDRISKLIPPDPGMTLEKAFKAEPQL
PEVYESDEEVKDLIDMARILEGVTRNAGKHAGGVVIAPTTITDFSPLYCDDEGKNPVTQF
DKNDVETAGLVKFDFLGLRTLTIIQWAIDMIKEGKNVDVDISAIPLEDPKSFRTLQNAET
TAVFQLESRGMKELIKRLKPDCFEDIIALVALFRPGPLQSGMVDNFIDRKHGREEISYPD
AEYQHECLKEILEPTYGIILYQEQVMQIAQEMAGYSLGGADLLRRAMGKKKPEEMAKQRG
TFAEGAKGNNIDPDLAMKIFDLVEKFAGYGFNKSHSAAYALVSYQTLWLKVHYPAEFMAA
VMSADMDNTDKIVTLVDECERMGIEILPPDLNAGKYKFTVDSEGRIVYGIGAIKGVGEGP
IEAIIEARETQGAFKDLFDFCAKIDIKRVNKRVLEKLVLAGAMDNLGPHRASLMASLPEA
LAAAGQHAKAESFGQSDMFGLLTTEPEDVKQAFADVPEWPEKVWLEGEKDTLGLYLTGHP
INQYAEELRYYTDGRLVDLKPTNKDQMASAVGLVLGVRVMTNKRGRRWAIVTLDDKSARI
DVRFFPDMYEQFESVLETDRILLIKGQVSFDDFSGGNTITARDVMDIVQAREKNARALAL
NIDTQLLEPKKMSQMQSILQAFNGGSCPVQLAVTHPDAEVILACGARWYVTPEDQLLHDL
KQCLGDKAVSILYH