Protein Info for MIT1002_00952 in Alteromonas macleodii MIT1002

Annotation: CTP synthase

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

• TIGR00337: CTP synthase
  • amino acids 2 to 534 (533 residues), 853.4 bits, E=3.2e-261
• PF06418: CTP_synth_N
  • amino acids 4 to 265 (262 residues), 414.4 bits, E=3e-128
• PF00117: GATase
  • amino acids 300 to 533 (234 residues), 148.8 bits, E=2.3e-47

Best Hits

Swiss-Prot: 99% identical to PYRG_ALTMD: CTP synthase (pyrG) from Alteromonas mediterranea (strain DSM 17117 / CIP 110805 / LMG 28347 / Deep ecotype)

KEGG orthology group: K01937, CTP synthase [EC: 6.3.4.2] (inferred from 99% identity to amc:MADE_03082)

MetaCyc: 75% identical to CTP synthetase (Escherichia coli K-12 substr. MG1655)
CTP synthase. [EC: 6.3.4.2]

Predicted SEED Role

"CTP synthase (EC 6.3.4.2)" (EC 6.3.4.2)

MetaCyc Pathways

• superpathway of histidine, purine, and pyrimidine biosynthesis (43/46 steps found)
• superpathway of pyrimidine deoxyribonucleotides de novo biosynthesis (18/18 steps found)
• superpathway of pyrimidine ribonucleotides de novo biosynthesis (9/9 steps found)
• superpathway of pyrimidine ribonucleosides salvage (9/10 steps found)
• superpathway of pyrimidine nucleobases salvage (4/4 steps found)
• L-glutamate and L-glutamine biosynthesis (6/7 steps found)
• UTP and CTP de novo biosynthesis (3/3 steps found)
• ammonia assimilation cycle III (3/3 steps found)
• L-glutamate biosynthesis I (2/2 steps found)
• L-glutamine degradation I (1/1 steps found)
• L-citrulline biosynthesis (6/8 steps found)
• L-asparagine biosynthesis III (tRNA-dependent) (3/4 steps found)
• glutaminyl-tRNA^gln biosynthesis via transamidation (3/4 steps found)
• UTP and CTP dephosphorylation I (5/7 steps found)
• superpathway of L-citrulline metabolism (8/12 steps found)
• UTP and CTP dephosphorylation II (1/3 steps found)

KEGG Metabolic Maps

• Pyrimidine metabolism

Isozymes

No predicted isozymes

Use Curated BLAST to search for 6.3.4.2

Protein Sequence (543 amino acids)

>MIT1002_00952 CTP synthase (Alteromonas macleodii MIT1002)
MTNYIFVTGGVVSSLGKGIAAASLAAILEARGLTVTMLKLDPYINVDPGTMSPIQHGEVF
VTDDGAETDLDLGHYERFIRTRMTKRNNFTTGRVYEEVLKRERRGDYLGATIQVIPHITN
EIKRRVIEGAEGHDVAIVEVGGTVGDIESQPFLEAIRQLGTEVGRERAMFMHLTLVPYMP
ASGEVKTKPTQHSVKELRSIGIQPDILVCRSVGALPASERSKIALFTNVADKAVISLKDV
DSIYRIPAALKAQGMDQLVVDRFGLKCEEADLSEWEQVLYAESNPTAEVNIGMVGKYVEL
PDAYKSVNEALKHAGLKNRLTVNIHHIDSQDVESKGTQILEQLDAILVPGGFGERGIEGK
IAAARYARENKVPYLGICLGMQVALIEFARNVAGMENANSTEFDPETPYPVVGLITEWLD
AAGTTETRTENSDLGGTMRLGSQLCHLIEGTKVHEMYGNAEIYERHRHRYEVNNNLRDQI
EAAGLKVSGLSTDKRLVEVVEIPDHPWFIAGQFHPEFTSTPRDGHPLFTGFVAAAGKYQK
ENH