Protein Info for MIT1002_00902 in Alteromonas macleodii MIT1002

Annotation: Imidazolonepropionase

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 300 350 419 TIGR01224: imidazolonepropionase" amino acids 78 to 417 (340 residues), 439.7 bits, see alignment E=4e-136 PF01979: Amidohydro_1" amino acids 79 to 418 (340 residues), 63.7 bits, see alignment E=1.9e-21 PF07969: Amidohydro_3" amino acids 126 to 395 (270 residues), 50.4 bits, see alignment E=2.6e-17

Best Hits

Swiss-Prot: 81% identical to HUTI_ALTMD: Imidazolonepropionase (hutI) from Alteromonas mediterranea (strain DSM 17117 / CIP 110805 / LMG 28347 / Deep ecotype)

KEGG orthology group: K01468, imidazolonepropionase [EC: 3.5.2.7] (inferred from 81% identity to amc:MADE_03129)

MetaCyc: 54% identical to imidazolonepropionase (Pseudomonas fluorescens)
Imidazolonepropionase. [EC: 3.5.2.7]

Predicted SEED Role

"Imidazolonepropionase (EC 3.5.2.7)" in subsystem Histidine Degradation (EC 3.5.2.7)

MetaCyc Pathways

KEGG Metabolic Maps

Isozymes

No predicted isozymes

Use Curated BLAST to search for 3.5.2.7

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Compare to protein structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

Find the best match in UniProt

Protein Sequence (419 amino acids)

>MIT1002_00902 Imidazolonepropionase (Alteromonas macleodii MIT1002)
MGYQYDTLIYNVRIASMQDNELPYGELPPHAIAIKDGKIAALLPCDDSLDDVFEQAKSVI
DATTLIPQNEGSTPKHPWLLPGFIDCHTHLVYGGNRAEEFEMRLQGASYVDIAQRGGGIK
GTVEKTRRSDENTLLHTAIKRAKRLCEEGVTTIEVKSGYGLDLDTEVRMLRVAKSLEQHL
PVSIQTTYLGAHALPNEFADDSEGYIDFICNEALPHIASQNLADAVDVFCETIGFSTSQT
ERVFSCAQQHALPIKAHVEQLSDSKGAVLAAKYGALSVDHIEYLADSDIPLLAQSGTVAV
LLPGAFYYLSEVQKPPVDALRAHNVPMALATDFNPGSSPLASILTAINMGCVLFQLTPEE
ALRGATAHAASALGLHDRGVIEAGKLADLTLWDIETPAELAYCINGHRPIAVFKEGKHV