Protein Info for MIT1002_00870 in Alteromonas macleodii MIT1002

Annotation: Prolyl tripeptidyl peptidase precursor

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 300 350 400 450 500 550 600 650 708 signal peptide" amino acids 1 to 37 (37 residues), see Phobius details PF07676: PD40" amino acids 103 to 138 (36 residues), 34.9 bits, see alignment (E = 3.2e-12) amino acids 157 to 171 (15 residues), 17 bits, see alignment (E = 1.4e-06) amino acids 232 to 261 (30 residues), 17.6 bits, see alignment (E = 8.7e-07) amino acids 284 to 310 (27 residues), 22.9 bits, see alignment (E = 2e-08) PF00930: DPPIV_N" amino acids 218 to 304 (87 residues), 33.8 bits, see alignment E=4.7e-12 PF05448: AXE1" amino acids 443 to 588 (146 residues), 23.7 bits, see alignment E=5.4e-09 PF00326: Peptidase_S9" amino acids 489 to 695 (207 residues), 156.9 bits, see alignment E=1.6e-49

Best Hits

KEGG orthology group: None (inferred from 93% identity to amc:MADE_03155)

Predicted SEED Role

"Acylamino-acid-releasing enzyme (EC 3.4.19.1)" (EC 3.4.19.1)

MetaCyc Pathways

Isozymes

Compare fitness of predicted isozymes for: 3.4.19.1

Use Curated BLAST to search for 3.4.19.1

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Search structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

Find the best match in UniProt

Protein Sequence (708 amino acids)

>MIT1002_00870 Prolyl tripeptidyl peptidase precursor (Alteromonas macleodii MIT1002)
MSFTRNHRYPSVKKRFAIWAALFSVGTLAMPSTALASNERESLTTDSERYFKSEDIFNLE
YVSEVQVSPNGKYVAYVRRSNDIMSDSSRANVWLASVDGKSHRPLLSSKKSYYSIRWSPD
GSRLAYLSNEEGKPQLYVRWMDTGQTALVTNVTSNPSNITWSPDGKHIAFTMSVDAKEKP
LDIKMPKKPDGAKWSPSFQYITKARYQADGRGILEPAYTHIFIVPADGGTARQLTSGNYH
HNGRLSFSPDSDKIYFSANRSDNWEYEPVEGDIFSVDMMGNIAQLTNDKGLESSPVVSPD
GKHIAYARRDDEKVMYKNSYLYVMKSDGTDAKNLTKDVDNSVSNFHWKDNKHVYFQQSVR
GLAQVDVVSLSGSVKAVAKGLGGTTLGRPYVFGTYHAVDDVVAYTKGRTDRPADLYVTTR
NERQLTALNEDVLGHKQLGEVKEIVYPSSIDGEEIQGWYILPPNYDSSKTYPLILEIHGG
PNLAYGPVFTAELQRMAAEGYVVFYDNHRGSTGYGERFALLLQGKYSSEYDFSDHMSGVD
ALIEKGIADPERLFITGGSAGGIASAYAIGLTNRFKAAVVAKPVINWLSKVLTADSGLYQ
IPFQFPGMPWDNVEHYWKRSPLSLVGNVTTPTMLITGVEDKRTPMSETEQFYQALKIQKV
DSVLVKVPGSPHGIASKPSRMIGKVENILAWFKKYDSVQSQSTQVEAQ