Protein Info for MIT1002_00856 in Alteromonas macleodii MIT1002

Annotation: Autoinducer 2 sensor kinase/phosphatase LuxQ

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 300 350 400 450 500 550 600 650 700 750 800 850 900 959 transmembrane" amino acids 20 to 40 (21 residues), see Phobius details amino acids 155 to 173 (19 residues), see Phobius details amino acids 248 to 271 (24 residues), see Phobius details PF13188: PAS_8" amino acids 445 to 495 (51 residues), 20.1 bits, see alignment 1.8e-07 TIGR00229: PAS domain S-box protein" amino acids 445 to 562 (118 residues), 63.7 bits, see alignment E=9e-22 PF00989: PAS" amino acids 450 to 553 (104 residues), 40.4 bits, see alignment E=1.1e-13 PF13426: PAS_9" amino acids 464 to 555 (92 residues), 69.2 bits, see alignment E=1.3e-22 PF08448: PAS_4" amino acids 465 to 558 (94 residues), 35 bits, see alignment E=5.8e-12 PF08447: PAS_3" amino acids 465 to 549 (85 residues), 32.1 bits, see alignment E=4.6e-11 PF00512: HisKA" amino acids 577 to 641 (65 residues), 69.8 bits, see alignment 6.7e-23 PF02518: HATPase_c" amino acids 688 to 803 (116 residues), 96.3 bits, see alignment E=6.2e-31 PF00072: Response_reg" amino acids 829 to 943 (115 residues), 87.3 bits, see alignment E=3.2e-28

Best Hits

KEGG orthology group: None (inferred from 87% identity to amc:MADE_03166)

Predicted SEED Role

"multi-sensor hybrid histidine kinase"

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Compare to protein structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

Find the best match in UniProt

Protein Sequence (959 amino acids)

>MIT1002_00856 Autoinducer 2 sensor kinase/phosphatase LuxQ (Alteromonas macleodii MIT1002)
MMQQPPRLRSLLLSSMLPRLVLLVAVLSIILFALSFHFIVKQTDQLQQQSVDGLEQDINY
IVSDTTRQLADLAANDIIINSLVDFEQRDNYLPMFFRSLNLTQAKSVEFALFDFAGNRVI
DKNWNAVIPESLSSAWRQQTLGSSNAYSSVSKYGVLISVPVLLRGVAEGALVMYVDSLQS
LLAPYPRLTNQLVTDSSGHVLFSSEPSLIAPNSSFSDFDDSGYAIKKADWQNLTLYSVKP
TITAYREAAWTGIVLLAMIVGFVFIILHMVSMTGTLAERTLSTLYNDIKNRLNSDDKTSL
RLDSEVEAQELADIREAFDKLIWDLTEVSLSNEQFSNVLESMGDMLVVVDQDKKILLSNK
RFDDFCHDQYGEKNGILKFIMQKLASSQSNELTHFSVSTGQERFVHWTKTSLADANGNIR
GDIYVGSDETEQRSLESHVKVLTHAMDEATVSIIISDIKRVGQPIIYVNSAFEELTGYSR
EEIIGHNCRSMQGDETSKQTVDQIREAIAVREPIETTLLNYKKDGSAFYNRLNLTPVKIN
GEVTHYIGFQQDVTQQRQTEQYLQDAREKAEESARLKSSFLASMSHEIRTPIHGISGVLQ
LMASSELTEEQKHYLSLAKFSIQGLLHIVNDILDFSKIEAGQLQIEENPFDILESLENLQ
SQYAIMCQEKGLALHFHFDLQGFHVVQGDDVRFRQILSNLLGNAVKFTDSGCIEVTTSIQ
QNADNSLRLLCSVKDTGIGIAQDKQSTIFDVFTQEDLSTTRKFGGTGLGLSISKQLCELM
GGDIKLESVKGHGSTFSFTIMLEQADEALLKPVHHSSGVKREKGKKRKVLIVEDNDINQV
IVKQHLNNHTTLSAKSGLEALEALNKMKVTFDVVLMDCQMPEMDGFEATKRIRNGEAGER
YLNVPIIALTANAMKGDKERCVNAGMDDYLSKPFDAIDLIDKVEHWASIERNSEESVVH