Protein Info for MIT1002_00850 in Alteromonas macleodii MIT1002

Annotation: potassium/proton antiporter

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 300 350 400 450 487 transmembrane" amino acids 6 to 24 (19 residues), see Phobius details amino acids 31 to 52 (22 residues), see Phobius details amino acids 58 to 78 (21 residues), see Phobius details amino acids 90 to 112 (23 residues), see Phobius details amino acids 119 to 139 (21 residues), see Phobius details amino acids 159 to 177 (19 residues), see Phobius details amino acids 189 to 212 (24 residues), see Phobius details amino acids 219 to 239 (21 residues), see Phobius details amino acids 245 to 262 (18 residues), see Phobius details amino acids 270 to 291 (22 residues), see Phobius details amino acids 303 to 324 (22 residues), see Phobius details amino acids 333 to 356 (24 residues), see Phobius details amino acids 362 to 382 (21 residues), see Phobius details PF00999: Na_H_Exchanger" amino acids 11 to 384 (374 residues), 173.4 bits, see alignment E=7.1e-55 PF02080: TrkA_C" amino acids 415 to 471 (57 residues), 44 bits, see alignment 1.7e-15

Best Hits

KEGG orthology group: K11105, cell volume regulation protein A (inferred from 96% identity to amc:MADE_03170)

Predicted SEED Role

"Cell volume regulation protein A"

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Search structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

Find the best match in UniProt

Protein Sequence (487 amino acids)

>MIT1002_00850 potassium/proton antiporter (Alteromonas macleodii MIT1002)
MFAVDHIILLSAVLAILGVLASKLSPRFGVPVLVLFLGVGMLAGEDGIGRIFFDNADAAH
AIGTFALILILFDGGLQTSKKSIAQAWKPAALLATFGVIGTAVVTGIAAMVILDLPLYKG
LLLGAIVGSTDAAAVFSVLRNAGIRIPSKIKSTLELESASNDPMAIFLTIGLITLIQDST
TKPVDLLSLFASQMGVGAIVGLAIGGIAVWLFRRVTLMAIGLYPVFVMLFGVLSFGLAAN
LNGSGFLATFITGVIVGNSRFAYQRNTFVFLDGLAWLGQIAMFVILGLLVTPTELFVNWK
EGLLIAFVLIFIARPLVVMPILLLSKFSFKASLLISWVGLRGSVPIILAIFPLIFGMPYA
ELIFNVVFFIVLISALLQGSTLPYAARKLGLVLDDEVKESSTLEIVKVAKSKRELIEIEV
SKLSPALHKTISELALPDNTVVAMIARGEETLIPKGSTKIEMGDQIFIITKLLDKSAVEH
CFYSEQE