Protein Info for MIT1002_00640 in Alteromonas macleodii MIT1002

Annotation: putative efflux pump membrane transporter TtgB

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 100 200 300 400 500 600 700 800 900 1000 1075 transmembrane" amino acids 29 to 54 (26 residues), see Phobius details amino acids 356 to 378 (23 residues), see Phobius details amino acids 382 to 401 (20 residues), see Phobius details amino acids 414 to 436 (23 residues), see Phobius details amino acids 457 to 477 (21 residues), see Phobius details amino acids 485 to 504 (20 residues), see Phobius details amino acids 557 to 580 (24 residues), see Phobius details amino acids 891 to 910 (20 residues), see Phobius details amino acids 917 to 935 (19 residues), see Phobius details amino acids 941 to 964 (24 residues), see Phobius details amino acids 989 to 1007 (19 residues), see Phobius details amino acids 1024 to 1046 (23 residues), see Phobius details PF00873: ACR_tran" amino acids 30 to 1044 (1015 residues), 470.2 bits, see alignment E=1.3e-144 PF03176: MMPL" amino acids 871 to 1045 (175 residues), 35.3 bits, see alignment E=6.5e-13

Best Hits

KEGG orthology group: None (inferred from 82% identity to alt:ambt_15445)

Predicted SEED Role

"Acriflavin resistance protein" in subsystem Multidrug Resistance Efflux Pumps

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Search structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

Find the best match in UniProt

Protein Sequence (1075 amino acids)

>MIT1002_00640 putative efflux pump membrane transporter TtgB (Alteromonas macleodii MIT1002)
MTNNRNGAPFDGGESPKGNRNSGNNSRGIIAWFAQNSVAANLLMVSLIVLGLVSMNNIRK
EAFPSMEPRFVTISMTYDSGDPKQAEEGIAIKIETALEAIPGIKRITSTSNASGASVQVE
KETEYDLDTLFNDIKTEVDSISNFPSDAENPVISKARRQEHAIWVQLYGDVDHASLQYLG
EQLERDLLATDDIREVSAGSFVDPMMSIEIDEGKLQAYGLTLSDVADVVNQESNTALTTS
LRNKEKVIRLKASEQSYWAKDFANIPLITDTNGVILTVGDVATVRDMFADDSYHLSRYNG
TNGYGIQVLMDEYGDVTKMVQQAHEVVDAWHEKGLLPEGVELETWYDKSTLITERLTLLT
SNALMGIVLVFVTLAVFLNLRVAFWVAAGLPFIFFGTLYFMTDSYTGMTLNEMTTFGFIM
ALGIVVDDAVVVGESVYATRKQHGDTLQNTILGTHKVAVPTLFGVLTTVATFFALSNVSG
GLGTLYSQFGTIVTLCLLLSVVESKLILPSHLAHLPTKQKARRGLGGVWNKVQQKADGGL
QWFNYRVYQRLLKVTVAYRYAAVLLFIALFVMVVSLPLTGAVRVSFFPSMQGDTVSANMS
LYSDASYGQNERNLMLLEKNALEADRQLTQENGADRSGISSLQVTASGDQSGTVTISLDE
DSSYSLDELSARWNALTGNLEGVKSLKIRSRREMVDGFNVEIKSINDDTLTAANDAFIEV
LNNIDGVYAVESSLTPGEAMMRFELTPEGRALGLNTQSLSQQLLKAFGGEIVQRYLRDKN
EVKVRVRYPEQDRMNPSDVMNTQVRLDDGTVVPLSVVANVIQDVQEKQVVRIDGLRALTV
SASVDSDVITSTELVNYLNNEFVPQLSRQYQDLSLYFAGEAEQQAETQSSMQSVFILALL
SIFALLAIPLKSYVQPLIIMTAIPFGIVGAIIGHWSNGLMISLLSLNGILALSGVVVNDS
LLLVSRFNALRDEGVPVETAVIEACTSRLRAVLLTSITTFVGLYPILGETSVQAQFLIPA
AASLGYGILFATVITLLLIPALLLIYDDVSRLMAKHLVKPLTESTANDPRVTSGR