Protein Info for MIT1002_00637 in Alteromonas macleodii MIT1002

Annotation: Bifunctional protein PutA

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 100 200 300 400 500 600 700 800 900 1000 1100 1200 1265 PF18327: PRODH" amino acids 11 to 58 (48 residues), 44.8 bits, see alignment (E = 2.5e-15) PF14850: Pro_dh-DNA_bdg" amino acids 67 to 180 (114 residues), 152.8 bits, see alignment E=9.3e-49 PF01619: Pro_dh" amino acids 190 to 482 (293 residues), 342.4 bits, see alignment E=4.6e-106 TIGR01238: delta-1-pyrroline-5-carboxylate dehydrogenase" amino acids 519 to 1005 (487 residues), 654.4 bits, see alignment E=5.3e-201 PF00171: Aldedh" amino acids 563 to 1001 (439 residues), 390.4 bits, see alignment E=2.1e-120

Best Hits

KEGG orthology group: K13821, proline dehydrogenase / delta 1-pyrroline-5-carboxylate dehydrogenase [EC: 1.5.1.12 1.5.99.8] (inferred from 97% identity to amc:MADE_03716)

Predicted SEED Role

"Proline dehydrogenase (EC 1.5.99.8) (Proline oxidase) / Delta-1-pyrroline-5-carboxylate dehydrogenase (EC 1.5.1.12)" in subsystem Arginine and Ornithine Degradation or Proline, 4-hydroxyproline uptake and utilization or Respiratory dehydrogenases 1 (EC 1.5.1.12, EC 1.5.99.8)

MetaCyc Pathways

KEGG Metabolic Maps

Isozymes

Compare fitness of predicted isozymes for: 1.5.1.12

Use Curated BLAST to search for 1.5.1.12 or 1.5.99.8

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Compare to protein structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

Find the best match in UniProt

Protein Sequence (1265 amino acids)

>MIT1002_00637 Bifunctional protein PutA (Alteromonas macleodii MIT1002)
MLINDTLHTTSPLRQRIRDYYRISESVAVDQILPIAEVNPRARSRAWERARKMVLQIRRE
QEGHGGVDALLNEYSLSTAEGVVLMCLAEALLRVPDKATQDELIRDKLSQGQWTPHLGNS
ESLFVNASAWGLLFTGNMVNYADKRKKEQFGLLKQTLGRLGEPVIRRAMNIAMRVMGRQF
VMGETIEDAVDRAKEKETKGYVYSYDMLGEGARTMRDAERYYDAYVKAIKVIGKAANGRG
PKRSPGISVKLSAIHPRFEFSHRERAMADIPPRLKALCMMAKEYDIGLTVDAEEADRLEL
SLDIIETVFRDEDLNGWTGFGLAVQAYQKRAIHVIEHLRELTLEVGRPLMVRLVKGAYWD
TEIKLTQQAGLEEFPVFTRKSSTDVSYHACANRLLEYRDTIYPQFATHNAYTASVIVELA
GDDKEGFEFQCLHGMGDTLYDQVVTQDKIQCRVYAPVGEHEDLLAYLVRRLLENGANSSF
VNAIVDDEKPVESLLEDPVEKTQRLKVRYNKLIKTPRGLYAPERDNSRGLDLTDTNAVTA
LKHELERWQDYYKVTGEVPEGATAVLSPTNHNDVVGYHHYATPDDMRKALDEAEAGFEAW
SKRDVSERAEILNRTADALERHMAELIAICMREAGKVAQDSIDEVREAVDFCRYYAARAE
ELAEDQRLLPRGVVLCISPWNFPLAIFLGQVAAALVTGNTVIAKPAEQTSIIAQRAVDIM
HSVGLPEDALKLIVSPGKEVGETLLPDERIKAVMFTGSTQTGTLISQVLAERGGEQVPLI
AETGGQNCMIVDSTALPEQVVDDVIHSGFQSAGQRCSALRVLFVQDEIADDLIEMLTGAM
KELTVGDPTQLATDVGPVIDEKALKSLTDHQEYMEDKAKLLYRNEMPAGFENGTFFAPTL
YEIKNIDVLEKEVFGPVVHIVRFKSKDLDSVLEQINGTGYGLTMGIHSRIEERANELAAK
SRAGNVYINRNMIGAIVGVQPFGGRGLSGTGPKAGGPNYLPRLMMERATPKPSHIDDVDG
TDAALVGDEKIAERAHVMMDKAKAVEVQWRHTPLNDRISMVRQLLAKIAKVDIVDELADD
LNRTLATARQQLTSVERKLAKPQTLPGPTGESNKLYLEPRGILVCFADKEVTFEYWLLSI
VTALSTGNPVVSVVSEIFYEEAVEIQNKFESTGAPKGLFQVARLAHLDTLLMDEDLSGVV
VDSGTERTARITAMLSSREGAILPVITAEYNDNLIQRLMTEKTISIDTTASGGNTSLMTL
VEDDE