Protein Info for MIT1002_00541 in Alteromonas macleodii MIT1002

Annotation: Mechanosensitive ion channel

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 300 356 transmembrane" amino acids 22 to 47 (26 residues), see Phobius details amino acids 61 to 80 (20 residues), see Phobius details amino acids 90 to 117 (28 residues), see Phobius details PF00924: MS_channel_2nd" amino acids 109 to 170 (62 residues), 47.3 bits, see alignment E=8.8e-17

Best Hits

KEGG orthology group: None (inferred from 90% identity to amc:MADE_00593)

Predicted SEED Role

"Mechanosensitive ion channel"

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Compare to protein structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

Find the best match in UniProt

Protein Sequence (356 amino acids)

>MIT1002_00541 Mechanosensitive ion channel (Alteromonas macleodii MIT1002)
MNTTNTSGATQTSLVDTALSALFPFVPLLVAIVLVISALIALHYLLLAKQSHLTSEQKLP
RQVGMLVLTIIGAVVIAMTLPVRESTRNQVIALIGVLISGVIAFSSTTMVGNLMAGIVLR
VNRPFKVGDFIKVEGYSGRVTEMGLLDVEIQTESRELIAFANTLMVNSPVSVTRASGAIV
SVDISLGYDIHHSIIEKHLLVAAENAQLLEPFVQVVGLGDFSVSYRISGLLTEVKSLLSA
RSRLHKAVLDALHNADIEIVSPSFMNQRPQPDGLKMIAKSPGHTKQEEASPEDVIFDKAE
EAEQKEKSKETLMQTIADIDAKIAESDGENRDELKHQKATAEAQLAALVKTKNEEG