Protein Info for MIT1002_00527 in Alteromonas macleodii MIT1002

Annotation: Prolyl tripeptidyl peptidase precursor

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 300 350 400 450 500 550 600 650 702 signal peptide" amino acids 1 to 35 (35 residues), see Phobius details PF00930: DPPIV_N" amino acids 211 to 303 (93 residues), 38.8 bits, see alignment E=2e-13 PF07676: PD40" amino acids 280 to 304 (25 residues), 25.9 bits, see alignment (E = 3.1e-09) PF00326: Peptidase_S9" amino acids 488 to 697 (210 residues), 172.3 bits, see alignment E=4.4e-54 PF01738: DLH" amino acids 523 to 679 (157 residues), 26.2 bits, see alignment E=2.4e-09

Best Hits

KEGG orthology group: None (inferred from 85% identity to amc:MADE_00579)

Predicted SEED Role

"Acylamino-acid-releasing enzyme (EC 3.4.19.1)" (EC 3.4.19.1)

MetaCyc Pathways

Isozymes

Compare fitness of predicted isozymes for: 3.4.19.1

Use Curated BLAST to search for 3.4.19.1

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Compare to protein structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

Find the best match in UniProt

Protein Sequence (702 amino acids)

>MIT1002_00527 Prolyl tripeptidyl peptidase precursor (Alteromonas macleodii MIT1002)
MFASRFAFRPVRKGLCVTSTALSLLVLGISQANALQESASDSTSLNALTYDDTFNLEFVA
NPQFLNKDTVIYSRQSMDVMTDGRQSRLWQVNIKSGEHRPFIGVDENLSQATLSPNGKMV
AYTKSVNGRAQIHLFYLDTMQSVRLTNTSEAPRQLTWSHDSKTLAFTQFTEEKQKPLFTG
MPSKPKGAKWADQGTYIDAVQYRGDGRGYLREGFDQIFVLPVEGGTPRQLTTGKFPSGGT
LSFSKENDWIYFATPQREDYALHPLFSNIYKVNVNTAAVEQVTDIEGPEGRPTLSPDGKY
LAFTQLNDRKLSYQNGDLVVLELESGDITRLTTSLDRSLGKFEWRKDSRGLIFSYLDHGE
TKLAAVNLKGDVKPIDVSIGGQAFGRPYTSGDFAVSDKGDIVYTMASRTVPGDLALYRKG
KDDTQLTDLNSDALGHKTLAEVQDLSVVSSVDELSIDAWIALPPGFDSSKKYPLILEIHG
GPHAAYGPHFAMEIQLMAAQGYVVVWSNPRGSSSYGEDFGNLIHHNYPSEDYNDLMDVVD
AVVKQGYVDSENLFITGGSGGGTLTAWSIGKTDRFSAAVVAKPVINWMSFSLTADAYPYF
SNYWMADMPWTIADKLWQRSPLSLVGNVVTPTMLLTGEADHRTPISETEQYYQALKLQGV
DAAMVRIPGASHGIASRPSRLIQKVGNIVAWFERYKKNNDGE