Protein Info for MIT1002_00520 in Alteromonas macleodii MIT1002

Annotation: Sodium/proton antiporter NhaA

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 300 350 424 transmembrane" amino acids 30 to 50 (21 residues), see Phobius details amino acids 75 to 93 (19 residues), see Phobius details amino acids 111 to 131 (21 residues), see Phobius details amino acids 137 to 160 (24 residues), see Phobius details amino acids 170 to 190 (21 residues), see Phobius details amino acids 195 to 213 (19 residues), see Phobius details amino acids 224 to 253 (30 residues), see Phobius details amino acids 273 to 295 (23 residues), see Phobius details amino acids 306 to 330 (25 residues), see Phobius details amino acids 345 to 369 (25 residues), see Phobius details amino acids 381 to 401 (21 residues), see Phobius details PF06965: Na_H_antiport_1" amino acids 23 to 398 (376 residues), 497.7 bits, see alignment E=1e-153 TIGR00773: Na+/H+ antiporter NhaA" amino acids 24 to 398 (375 residues), 457.3 bits, see alignment E=1.9e-141

Best Hits

Swiss-Prot: 58% identical to NHAA_PSYCK: Na(+)/H(+) antiporter NhaA (nhaA) from Psychrobacter cryohalolentis (strain K5)

KEGG orthology group: K03313, Na+:H+ antiporter, NhaA family (inferred from 95% identity to amc:MADE_00573)

Predicted SEED Role

"Na+/H+ antiporter NhaA type" in subsystem Na(+) H(+) antiporter

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Search structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

Find the best match in UniProt

Protein Sequence (424 amino acids)

>MIT1002_00520 Sodium/proton antiporter NhaA (Alteromonas macleodii MIT1002)
MTDKHEPDVLDEVIEEVQDVVSDFLNREAAPGILLMGATILALIIANSPLDTLYDHLISM
PVQISAGTWAIDKPLLLWINDGLMAVFFFHVGLELKREICEGELANPKDIILPAAGAVGG
MALPALIYVGINWDNPVAIAGWAIPAATDIAFALGILALLGSRVPTSLKVFLVTLAIIDD
IGAIVIIALFYTEHITAGALYIAAGCLLLLWQMNKRNVVDIPPYVFVGIILWVAMLKSGV
HATLAGVVLAGFIPMRDEKDESYSPVTRLEHGLNGSVSFAILPLFAFANAGISFGNISPE
GIFHPVTFGIFLGLVVGKQIGVFGFCYLMVKLKLAKLPEDLNFKHIYGCALLCGVGFTMS
LFIGGLAFAQTGINQIFDERVGILTGSLVSACLGYIVLRFVSEAPIDNTDVASNASKFTG
NTVK