Protein Info for MIT1002_00423 in Alteromonas macleodii MIT1002

Annotation: Aspartate carbamoyltransferase catalytic chain

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

• TIGR00670: aspartate carbamoyltransferase
  • amino acids 7 to 315 (309 residues), 308.6 bits, E=2.1e-96
• PF02729: OTCace_N
  • amino acids 8 to 148 (141 residues), 160.8 bits, E=2.5e-51
• PF00185: OTCace
  • amino acids 159 to 314 (156 residues), 79.1 bits, E=3.9e-26

Best Hits

Swiss-Prot: 71% identical to PYRB_CELJU: Aspartate carbamoyltransferase (pyrB) from Cellvibrio japonicus (strain Ueda107)

KEGG orthology group: K00609, aspartate carbamoyltransferase catalytic subunit [EC: 2.1.3.2] (inferred from 99% identity to amc:MADE_00485)

Predicted SEED Role

"Aspartate carbamoyltransferase (EC 2.1.3.2)" in subsystem De Novo Pyrimidine Synthesis (EC 2.1.3.2)

MetaCyc Pathways

• superpathway of histidine, purine, and pyrimidine biosynthesis (43/46 steps found)
• superpathway of pyrimidine deoxyribonucleotides de novo biosynthesis (18/18 steps found)
• superpathway of pyrimidine ribonucleotides de novo biosynthesis (9/9 steps found)
• UMP biosynthesis I (6/6 steps found)
• UMP biosynthesis II (6/6 steps found)
• UMP biosynthesis III (5/6 steps found)

KEGG Metabolic Maps

• Alanine and aspartate metabolism
• Pyrimidine metabolism

Isozymes

No predicted isozymes

Use Curated BLAST to search for 2.1.3.2

Protein Sequence (337 amino acids)

>MIT1002_00423 Aspartate carbamoyltransferase catalytic chain (Alteromonas macleodii MIT1002)
MSDFTGNHILSVNQFDREAIEKVFSVANSMQPYAKRQKRTTVLDGAILGNLFFEPSTRTR
VSFGTAFNLLGGEVRETTGMSSSALAKGESLYDTARVLSGYSDIIAMRHPAAGSVAEFAE
GSRVPVINGGDGANEHPTQALLDLFTIKRELEYNGHGIDGLHIAMIGDLRYGRTVHSLSR
LLCLFKNIRFTLISPKELAMPQPIIDAIVNAGHQLTITDTLEGNMDADICYQTRIQEERF
PSQEEANKYRGKFRLNQSIYTKHFQSKTVIMHPLPRDSRMEANELDNDLNLNPNLAIFRQ
TDNGVLVRMALFALTLGVENLLTKYERDVVWYSNKSK