Protein Info for MIT1002_00312 in Alteromonas macleodii MIT1002

Annotation: Cation efflux system protein CzcA

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 100 200 300 400 500 600 700 800 900 1048 transmembrane" amino acids 13 to 31 (19 residues), see Phobius details amino acids 344 to 362 (19 residues), see Phobius details amino acids 368 to 387 (20 residues), see Phobius details amino acids 395 to 414 (20 residues), see Phobius details amino acids 449 to 468 (20 residues), see Phobius details amino acids 478 to 504 (27 residues), see Phobius details amino acids 534 to 554 (21 residues), see Phobius details amino acids 873 to 892 (20 residues), see Phobius details amino acids 899 to 918 (20 residues), see Phobius details amino acids 924 to 949 (26 residues), see Phobius details amino acids 971 to 990 (20 residues), see Phobius details amino acids 1002 to 1025 (24 residues), see Phobius details TIGR00914: heavy metal efflux pump, CzcA family" amino acids 1 to 1038 (1038 residues), 1441.4 bits, see alignment E=0 PF00873: ACR_tran" amino acids 5 to 1029 (1025 residues), 1017 bits, see alignment E=0

Best Hits

Swiss-Prot: 56% identical to CZCA_ALCSC: Cation efflux system protein CzcA (czcA) from Alcaligenes sp. (strain CT14)

KEGG orthology group: K07239, heavy-metal exporter, HME family (inferred from 100% identity to amc:MADE_00305)

MetaCyc: 56% identical to cation efflux system protein (Pseudomonas putida KT2440)
RXN1G01-61; TRANS-RXN0-200; TRANS-RXN0-244

Predicted SEED Role

"Cobalt-zinc-cadmium resistance protein CzcA; Cation efflux system protein CusA"

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Compare to protein structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

Find the best match in UniProt

Protein Sequence (1048 amino acids)

>MIT1002_00312 Cation efflux system protein CzcA (Alteromonas macleodii MIT1002)
MLDAILKFSIERSKLILVFVFAVAMLGLWNFQKLPIDAVPDITNVQVVINTEALGYTPLE
VEQRITFPLETALSGVPNLSYTRSVSRYGLSQVVAIFNDDTDIYFARQLVNERINAAKSE
LPSGLEPELGPISTGLGEIFMFTVDAKEGATNEDGRPISPTDLRTVHDWVIRPQLMQVEG
VVEVNPIGGFEREILIALNPDKLLLFGLTQQDVINAVGKHNSNKGAGFIEKNGAQWLIRL
PGQVETLKQISEIPLPTDLGKIVRVKDVAEVKEGKELRSGAATQNGREVVLSTVFMLIGE
NSQKVARGVGERIKEISASLPEGIVVNAVYDRTKLVNTTLDTVKMNLTEGAILVIVVLFL
LLGNIRAAFLTALVIPFAMLMTVTGMIQTRTTANLMSLGALDFGLLVDGAIIIVENCLRR
LSHATQKGELNAKQRLSLVYDATREVIRPALFGVFIITAVYLPIFALSGVEGKMFHPMAI
TVVIALVSAMVLSITFIPAAIALTFKGKVTEKENIIINTSVSLYRPALKVILKARWLVIT
VAFSLVILASFMGMRLGSEFVPNLDEGDIAMHALRIPGTSLSQSIAMQKVLEERIKALPE
VERVFAKIGTANVATDAVPPSVADNFIIIKPRSEWPNPNKTKEQLVAELEELVTPVPGNR
YEFLQPIQMRFNELLAGVRAELAIKVFGDDFDTLAELGKEIETAIQDVEGIRDVQVEQTK
GLPVLTFLPHREKLALYGLSLEDFQTQVAVSMGGQVAGKFYEGDKRFDIVARLPEEKRQD
VNSLSNLPISLPNGEHIPLKELADMEVILGANQVNRENGKRRVVVTANVRGRDLGSFVQD
IQAAIKSKVKLPASYWIEYGGTYQKLQSASERLSIVVPVTLVLIVLLLFLALGSIKDSLI
IFSGVPLALTGGIFALYLRGIPFSISAAVGFIALSGIAILNGLVLVSFIRDLISRNQLLE
SAIIEGAVTRLRPVITTALVASLGFIPMALNTGIGSEVQRPLATVVIGGVISSTILTLFV
LPALFRILHSNDKSEEHNSGNSLMKSEG