Protein Info for MIT1002_00252 in Alteromonas macleodii MIT1002

Annotation: Cation efflux system protein CusA

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 100 200 300 400 500 600 700 800 900 1045 transmembrane" amino acids 12 to 31 (20 residues), see Phobius details amino acids 339 to 358 (20 residues), see Phobius details amino acids 364 to 384 (21 residues), see Phobius details amino acids 390 to 411 (22 residues), see Phobius details amino acids 431 to 457 (27 residues), see Phobius details amino acids 477 to 498 (22 residues), see Phobius details amino acids 528 to 547 (20 residues), see Phobius details amino acids 865 to 883 (19 residues), see Phobius details amino acids 890 to 909 (20 residues), see Phobius details amino acids 915 to 941 (27 residues), see Phobius details amino acids 978 to 995 (18 residues), see Phobius details amino acids 1007 to 1033 (27 residues), see Phobius details TIGR00914: heavy metal efflux pump, CzcA family" amino acids 1 to 1037 (1037 residues), 1266.5 bits, see alignment E=0 PF00873: ACR_tran" amino acids 6 to 1032 (1027 residues), 789.5 bits, see alignment E=4.6e-241

Best Hits

Swiss-Prot: 59% identical to CUSA_ECOLI: Cation efflux system protein CusA (cusA) from Escherichia coli (strain K12)

KEGG orthology group: K07787, Cu(I)/Ag(I) efflux system membrane protein CusA (inferred from 100% identity to amc:MADE_00320)

MetaCyc: 59% identical to copper/silver export system RND permease (Escherichia coli K-12 substr. MG1655)
TRANS-RXN-90; TRANS-RXN0-280

Predicted SEED Role

"Cobalt-zinc-cadmium resistance protein CzcA; Cation efflux system protein CusA"

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Compare to protein structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

Find the best match in UniProt

Protein Sequence (1045 amino acids)

>MIT1002_00252 Cation efflux system protein CusA (Alteromonas macleodii MIT1002)
MIEAVIRWSVSNRFFVLLATIIIVGGGLVTMKNTPVDAIPDLSDVQVIIKTSYPGQAPQV
VEDQVTYPLTTAMLSVPGAQTVRGYSFFGDSYVYIIFDDDTDLYWARSRVLEYLSQVAPN
LPENARPQLGPDATGVGWVYLYALVDRTGQHDISQLRSLQDWFLKFELQTVPGVSEVSAL
GGMVKQYQVKVDPEKLRAYGIPLSHIQMAIKRGNQEVGASVVELAEAEYMVRATGYISDK
KDIETIPLGVNDNGTPLLIRDIATVDIGPQMRRGIAELNGEGETVGGIVVMRFGENAQKT
IDGVKAKLEDLKKGLPDGVEVVTVYDRSALIERAVDNLASKLLEEFIVVALVCVAFLFHV
RSSLVAIISIPVGIITALIVMYMQGINANIMSLGGIAIAIGAMSDGAIVMIENMHKHMEK
TPLTKENRWQVVIDSAVEVGPALFFSLLIITVSFVPVFTLEAQEGRMFSPLAYTKTYAMA
ASAALAITLVPVLMGYFVRGKVLPEHKNPVNKFLTFLYIPTLKTVLRFPKSTMVAALIVL
AIGVWPIDKIGSEFIPPLDEGDLMYMPTTYAGISIGKARELLQQTNKLIKTVPEVETVFG
KVGRADTATDPAPLTMIETFIQLKPKEQWREGMTTQDLIKEFDAVVNLPGLTNAWVMPIK
TRIDMLATGIKTPVGIKIGGPDLMEIQKIGQQIESILTDVDGTASVYSERVAGGRYLKVD
IDREKAARYGLNIADVQQIVSSAIGGVNVTQSVEGLERYPVNIRYPQSYRSSPESLSLLP
VVTPQGKRIALADVADVYIEDGPPGIKSENARLNGWVYVDIDGVDIGTYVATAQQVVAEQ
LVLPAGYSINWSGQYEYMLRAKEKLTYVVPLTLAIIVILLYLNFRNFIEVAIIMGTLPLS
MVGSIWLMYIEGFNFSVAVGVGFIALAGVAVEIGVIMLVYLNHEYQALMDRCKEGGTLPS
AEMLTEAVLHGAGLRVRPVMMTTATIIFGLLPVLYGSGTGSEVMSRIAAPMVGGMVSAII
LTLLILPAIYLIWRKQQLKYLAVVA